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UnknownA Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Not available
S-EPMC5581710 | biostudies-literature
UnknownTRK inhibitor activity and resistance in TRK fusion-positive cancers in adults.
Not available
S-EPMC9133157 | biostudies-literature
UnknownBasket trial of TRK inhibitors demonstrates efficacy in TRK fusion-positive cancers.
Not available
S-EPMC5992878 | biostudies-literature
Unknownp75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.
Not available
S-EPMC1369184 | biostudies-literature
UnknownTRK Inhibitors: Tissue-Agnostic Anti-Cancer Drugs.
Not available
S-EPMC8308490 | biostudies-literature
TranscriptomicsAnti-Tumor Activity of Entrectinib, a Pan-TRK, ROS1 and ALK Inhibitor, in ETV6-NTRK3-Positive Acute Myeloid Leukemia
Activation of TRK family tyrosine kinases by chromosomal rearrangement has been shown to drive a wide range of solid tumors and hematologic malignancies. TRK fusions are actionable targets as evidenced by recent clinical trial results in solid tumors. Entrectinib (RXDX-101) is an investigational, or...
ORGANISM(S): Homo sapiens 
2018-07-05 | GSE100885 | GEO
UnknownSelective, Intrinsically Fluorescent Trk Modulating Probes.
Not available
S-EPMC11487604 | biostudies-literature
UnknownJND4135, a New Type II TRK Inhibitor, Overcomes TRK xDFG and Other Mutation Resistance In Vitro and In Vivo.
Not available
S-EPMC9570838 | biostudies-literature
UnknownInhibiting TRK Proteins in Clinical Cancer Therapy.
Not available
S-EPMC5923360 | biostudies-literature
TranscriptomicsExpression data from Trk-overexpressing NB cell line SY5Y
Neurotrophin receptors play a pivotal role in the biology and prognosis of neuroblastoma (NB). While expression of TrkA/NTRK1 confers a good prognosis to NB patients, expression of TrkB/NTRK2 is associated with unfavorable outcome. We have transfected the neurotrophin-receptor null cell line SY5Y wi...
ORGANISM(S): Homo sapiens 
2009-10-05 | GSE18409 | GEO
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