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OtherElucidating the human tRNA transcriptome dependent upon the TRMT1 and TRMT1L paralogs for modification, stability, and function
The tRNA methyltransferase 1 (TRMT1) enzyme catalyzes the formation of dimethylguanosine (m2,2G) in tRNAs. Loss-of-function mutations in TRMT1 lead to intellectual disability disorders in humans. In addition to TRMT1, vertebrates encode a tRNA methyltransferase 1-like (TRMT1L) paralog. Here, we use ...
ORGANISM(S): Homo sapiens 
2024-08-09 | GSE263642 | GEO
GenomicsElucidating the human tRNA transcriptome dependent upon the TRMT1 and TRMT1L paralogs for modification, stability, and function
Elucidating the human tRNA transcriptome dependent upon the TRMT1 and TRMT1L paralogs for modification, stability, and function
PRJNA1098624 | ENA
UnknownBi-allelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder.
Not available
S-EPMC12120178 | biostudies-literature
UnknownRecognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease.
Not available
S-EPMC11706605 | biostudies-literature
UnknownRecognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease.
Not available
S-EPMC9980103 | biostudies-literature
UnknownProteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease.
Not available
S-EPMC11139479 | biostudies-literature
UnknownProteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease.
Not available
S-EPMC10370084 | biostudies-literature
UnknownAn intellectual disability-associated missense variant in TRMT1 impairs tRNA modification and reconstitution of enzymatic activity.
Not available
S-EPMC7981843 | biostudies-literature
UnknownTRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival.
Not available
S-EPMC5640816 | biostudies-literature
UnknownHuman TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs.
Not available
S-EPMC11831618 | biostudies-literature
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