Trna modifications

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Unknown (789)
Genomics (368)
Proteomics (267)
Transcriptomics (232)
Other (54)
Metabolomics (13)
Methylation profiling (5)
Multiomics (1)

Organisms

Homo sapiens (175)
Mus musculus (75)
Saccharomyces cerevisiae (47)
Drosophila melanogaster (9)
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Escherichia coli str. K-12 substr. MG1655 (5)
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Medicago truncatula (1)
Oryza sativa (1)

Organisms

Homo sapiens (101)
Mus musculus (30)
Saccharomyces cerevisiae (16)
Escherichia coli (6)
Pseudomonas aeruginosa UCBPP-PA14 (4)
Drosophila melanogaster (4)
Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 (2)
Sus scrofa (2)
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Schizosaccharomyces pombe (1)
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Entamoeba histolytica (1)
Pseudomonas aeruginosa (1)
Danio rerio (1)
Bacillus velezensis (1)
Rattus norvegicus (1)
synthetic construct (1)

Repository

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geo (206)
biostudies-arrayexpress (154)
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Tissue

Cell culture (50)
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Blood (3)
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Mild hyperglycemia, liver dysfunction, and renal glycosuria (1)
Teratozoospermia and infertility (1)
These mice have a relatively normal first wave of spermatogenesis but never become fertile. Older animals show increased apoptosis of germ cells, increasing in severity as germ cell stage advances. (1)
Chronic myeloid leukemia (1)
Acute leukemia (1)
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Multiple myeloma (1)
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Parkinson's disease (1)
Perrault syndrome (1)

Technology Type

Mass Spectrometry (225)
Shotgun proteomics (120)
Bottom-up proteomics (45)
Affinity purification coupled with mass spectrometry proteomics (39)
Data-dependent acquisition (32)
Gel-based experiment (11)
Mass spectrometry (9)
Data-independent acquisition (8)
SWATH MS (5)
Mass spectrometry assay (4)
Chemical cross-linking coupled with mass spectrometry proteomics (4)
SRM/MRM (4)
RNA mass spectrometry (3)
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Top-down proteomics (2)
DiaPASEF (1)
Immunopeptidomics (1)

Instrument Platform

Illumina NovaSeq 6000 (6)
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Axon GenePix4000B (1)
GenePix 4000A [Axon Instruments] (1)
Ion Torrent S5 XL (1)
Illumina HiSeq 4000 (1)
MicrOTOF-Q II (1)
Orbitrap Ascend (1)
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Xevo TQ MS (Waters) (1)
Liquid Chromatography MS - Alternating (LC-MS (Alt)) (1)

Publication Date

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2024 (72)
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2022 (66)
2023 (60)
2021 (55)
2013 (28)
2020 (22)
2019 (20)
2018 (18)
2016 (18)
2014 (18)
2010 (16)
2015 (15)
2012 (14)
2017 (11)
2011 (10)
2009 (8)
2008 (8)
2006 (6)
2005 (6)
2004 (3)

CHEBI ID

CHEBI:16750 (6)
CHEBI:16335 (6)
CHEBI:16704 (6)
CHEBI:17596 (5)
CHEBI:20129 (4)
CHEBI:20794 (4)
CHEBI:17562 (4)
CHEBI:21891 (4)
CHEBI:16020 (4)
CHEBI:68467 (3)
CHEBI:178092 (3)
CHEBI:19688 (3)
CHEBI:178091 (3)
CHEBI:19068 (3)
CHEBI:19229 (3)
CHEBI:19228 (3)
CHEBI:19702 (3)
CHEBI:89487 (3)
CHEBI:19227 (3)
CHEBI:19062 (3)
CHEBI:69426 (3)
CHEBI:16040 (3)
CHEBI:20607 (3)
CHEBI:17802 (3)
CHEBI:19065 (3)
CHEBI:45996 (3)
CHEBI:178090 (2)
CHEBI:60193 (2)
CHEBI:19928 (2)
CHEBI:20597 (2)

Metabolite Name

Adenosine (6)
Guanosine (5)
7-methylguanosine (4)
1-methyladenosine (4)
4-methylcytidine (3)
2'-O-methylinosine (3)
2'-O-methyluridine (3)
6-methyladenosine (3)
8-methyladenosine (3)
2-methyladenosine (3)
3-methyluridine (3)
5-methyluridine (3)
3-methylpseudouridine (3)
1-methylpseudouridine (3)
3-methylcytidine (3)
5-methylcytidine (3)
2'-O-methylguanosine (3)
2'-O-methylcytidine (3)
1-methylinosine (3)
Uracil (3)
Stearic acid (3)
Palmitic acid (3)
Myristic acid (3)
Cytidine (3)
Uridine (3)
L-Phenylalanine (3)
Inosine (3)
2-methylguanosine (2)
5-methoxycarbonylmethyluridine (2)
5-hydroxymethylcytidine (2)

First Public Date

2025 (64)
2026 (53)
2024 (43)
2023 (33)
2022 (26)
2021 (23)
2018 (12)
2020 (10)
2019 (10)
2014 (5)
2017 (4)
2015 (3)
2013 (3)
2016 (2)

Classification

bacteria (13)
protozoa (5)
fungi (2)

Modification

4x(2)H labeled dimethylated residue (1)
N6-dimethyl-L-lysine (1)

Study type

Transcription profiling by array (35)
RNA-seq of coding RNA (34)
ChIP-chip by array (17)
ChIP-seq (15)
RNA-seq of non coding RNA (15)
Other (11)
ChIP-chip by tiling array (9)
Unknown experiment type (3)
Comparative genomic hybridization by array (2)
RNA-seq of coding RNA from single cells (2)
Translation profiling (1)
High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
ATAC-seq (1)
Ribo-seq (1)
DNA-seq (1)
Methylation profiling by array (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of total RNA (1)

Release Date

2024 (89)
2025 (87)
2022 (79)
2020 (70)
2023 (67)
2021 (60)
2018 (56)
2019 (49)
2015 (48)
2017 (46)
2013 (44)
2016 (43)
2014 (40)
2012 (34)
2010 (28)
2011 (23)
2009 (18)
2005 (14)
2026 (12)
2008 (11)
2006 (8)
2007 (8)
2004 (4)
1998 (2)
2003 (1)
2002 (1)

Lab affiliation

Professor of Genomic Evolution, School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin Belfield Dublin 4 (11)
Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA. Systems Biology Institute, Yale University, New Haven, CT 06516, USA (7)
LMU Munich Plant Biochemistry and Physiology, Germany (6)
Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan. (4)
Professor and Tier 1 Canada Research Chair in Proteinase Proteomics and Systems Biology at the University of British Columbia, Centre for Blood Research (4)
University of Alabama at Birmingham, O'Neal Mass Spectrometry Proteomics Shared Facility (4)
Berlin Institute of Health at Charite, Universitaetsmedizin Berlin, Core Facility Proteomics; Max Delbrueck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany (3)
Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA. Systems Biology Institute, Yale University, New Haven, CT 06516, USA (3)
Department of Fundamental Neurosciences, Rue du Bugnon 9, 1005, Lausanne (3)
Institut Pasteur Unité "Plasticité du Génome Bactérien" Département Génomes et Génétique 28 rue du Docteur Roux 75724 Paris Cedex 15 (3)
Boston University Goldman School of Dental Medicine Boston MA, 02118, USA (2)
Department of Chemistry and Biochemistry University of Bern Switzerland (2)
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA (2)
Head of Lab of Cancer Signaling GIGA-institute Université de Liège CHU, B34, Tour GIGA (+2) B-4000 Liège (2)
Head of the Curie Institute Mass Spectrometry Platform (2)
Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main, Germany (2)
Lab Head, UQ Diamantina Institute,The University of Queensland (2)
Massachusetts Institute of Technology (2)
Medical University of Innsbruck - Biocenter, Division of Genomics & RNomics (2)
Quantitative Proteomics & Proteome Center Tuebingen Interfaculty Institute for Cell Biology University of Tuebingen Tuebingen Germany (2)
1Institute for Genetics, University of Cologne, Cologne, Germany. 2Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. 3Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany. (1)
Aging $ Metabolism, Gene Translation Laboratory, Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain. (1)
BGI-Shenzhen, Shenzhen, 518083,China (1)
Ben-Gurion University of the Negev (1)
Biological Engineering, CEHS, MIT (1)
Biology department, Stanford, USA (1)
Biozentrum, University of Basel (1)
Biozentrum, University of Basel, CH-4056 Basel, Switzerland (1)
Boston College, Chemistry (1)
CICS-UBI–Health Sciences Research Center, Universidade da Beira Interior, 6201-506 Covilhã, Portugal (1)

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Neuronal tRNA modifications in Aplysia californica are repatterned during behavioral habituation

Transfer RNA (tRNA) modifications have been increasingly implicated as post-transcriptional regulators of basic neuronal functions. However, characterizing tRNA modification profiles in specific neural circuits that control well-defined behaviors is notoriously difficult due to the complexity of con...

2026-09-01 | MTBLS15420 | MetaboLights

Identification of tRNA sequences in Lactococcus lactis

we report the identification and sequences of the tRNAome of industrially relevant microorganism Lactococcus lactis Three Next Generation sequencing runs annotated as S1, S2 and S3 were performed. Cells were harvested at exponential phase and tRNA was isolated. S1 and S2 were spiked with Phe-tRNAGAA...

ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363

2014-07-29 | E-GEOD-55392 | biostudies-arrayexpress

Loss of cytosine-5 methylation in tRNA triggers stress responses in a disease model for Intellectual Disability

Mutations in the cytosine-5 RNA methyltransferase NSun2 can cause Intellectual Disability (ID) and symptoms commonly found in patients with Dubowitz syndrome. By analysing gene expression data with the global cytosine-5 RNA methylome in NSun2-deficient mice, we find that loss of cytosine-5 RNA met...

ORGANISM(S): Mus musculus

2014-11-06 | E-GEOD-44746 | biostudies-arrayexpress

Profiling tRNA modifications in Mycobacterium tuberculosis

PRJNA1002795 | ENA

Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling

Transfer RNA (tRNA) modifications enhance the efficiency, specificity and fidelity of translation in all organisms. The anticodon modification mcm5s2U34 is required for normal growth and stress resistance in yeast; mutants lacking this modification have numerous phenotypes. Mutations in the homologo...

ORGANISM(S): Saccharomyces cerevisiae

2013-08-01 | E-GEOD-45366 | biostudies-arrayexpress

Genome-Wide Translation Profiling by Ribosome-Bound tRNA Capture

In the ribosome complex, tRNA is a critical element of mRNA translation. We reported a new technology for profiling ribosome-embedded tRNAs and their modifications. With the method, we generated a comprehensive survey of the quanity and quality of intra-ribosomal tRNAs (Ribo-tRNA-seq). Ribo-tRNA-seq...

ORGANISM(S): Saccharomyces cerevisiae

2018-03-19 | E-MTAB-6576 | biostudies-arrayexpress

Comparative tRNA-seq for rapid profiling of tRNA modifications in a non-model organism

PRJNA615798 | ENA

Dynamic changes in tRNA modifications and abundance during T-cell activation [tRNA-seq]

PRJNA694919 | ENA

Misactivation of multiple starvation responses in yeast by loss of tRNA modifications.

Not available

S-EPMC7367188 | biostudies-literature

Modifications in the T arm of tRNA globally determine tRNA function and cellular fitness

PRJNA977562 | ENA