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TranscriptomicsExpression data of human trophectoderm cells
The implantation process begins with attachment of the trophectoderm (TE) of the blastocyst to the maternal endometrial epithelium. Herein we have investigated the transcriptome of mural TE cells from 13 human blastocysts and compared these with those of human embryonic stem cell (hESC)-derived-TE (...
ORGANISM(S): Homo sapiens 
2011-09-08 | E-GEOD-30650 | biostudies-arrayexpress
TranscriptomicsComparison of the transcriptome of day 3 human embryo with that of the trophectoderm
In humans, the embryonic genome activation (EGA) program is functional by day 3 after fertilization. The 6-8 cell stage embryo (day 3 post-fertilization) starts the process of “compaction” that leads to the generation of the tightly organized cell mass of the morula and is followed by differentiatio...
ORGANISM(S): Homo sapiens 
2012-07-08 | E-GEOD-33025 | biostudies-arrayexpress
TranscriptomicsRNA-seq transcriptome profiling of equine inner cell mass and trophectoderm
Transcriptomic analysis of ICM and TE from in vivo-derived equine blastocysts using Illumina sequencing technology RNA was extracted from individual equine blastocyst ICM and TE (Arcturus Picopure), cDNA was synthesized and amplified (Nugen Ovation V2) and indexed libraries were created for sequenci...
ORGANISM(S): Equus caballus 
2014-05-02 | E-GEOD-51431 | biostudies-arrayexpress
TranscriptomicsSNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts
Preimplantation genetic diagnosis (PGD) of aneuploidy by fluorescence in situ hybridisation (FISH) has not delivered the expected clinical benefit. Many previous re-analysis studies of embryos deemed aneuploid by FISH on day 3 have found a high degree of chromosomal normalcy at the blastocyst stage...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-18932 | biostudies-arrayexpress
ProteomicsA Simple Human Embryo Model Reveals V-ATPase Requirement in Mammalian Blastocyst Cavitation
Human naïve pluripotent stem cells (nPSCs) can differentiate into trophectoderm (TE) and self-organize into embryo-like structures known as blastoids, typically requiring complex cocktails of signaling factors. Here, we demonstrate that dimethyl sulfoxide (DMSO) alone robustly induces TE differentia...
ORGANISM(S): Homo sapiens (Human) 
2026-03-12 | PXD069054 | Pride
Blastoids  trophectoderm differentiation  dimethyl sulfoxide  v-atpase  lysosomal acidification 
GenomicsAltered Subcellular Localization of Transcription Factor TEAD4 Regulates First Mammalian Cell Lineage Commitment
In the preimplantation mouse embryo TEAD4 is critical to establishing the trophectoderm (TE)-specific transcriptional program and segregating TE from the inner cell mass (ICM). However, TEAD4 is expressed both in the TE and the ICM. Thus, differential function of TEAD4 rather than expression itself ...
ORGANISM(S): Mus musculus 
2012-04-18 | E-GEOD-37350 | biostudies-arrayexpress
TranscriptomicsRNA-seq of bulk trophectoderm microdissected from human blastocysts cultured to day 5, day 6 and day 7 post-fertilisation
5 days after fertilisation the human embryo forms a blastocyst, comprising an outer layer of trophectoderm (TE), that gives rise to placental trophoblast cells, and the inner cell mass (ICM) which later segregates into epiblast (EPI) and primitive endoderm (PE). After implantation TE differentiates ...
ORGANISM(S): Homo sapiens 
2024-08-31 | E-MTAB-10749 | biostudies-arrayexpress
TranscriptomicsCell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing
It remains an open question when and how the first cell fate decision is made in mammals. Using deep single-cell RNA-seq of matched sister blastomeres, we report highly reproducible interblastomere differences among ten 2-cell and five 4-cell mouse embryos. Inter-blastomere gene expression differenc...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-57249 | biostudies-arrayexpress
TranscriptomicsEarly mouse embryo development
Expression profiling of mouse embryos at E2.5, E3.5, E4.25, E4.5, E5.5 E6.0 to identify genes regulated during development of the ICM (inner cell mass), TE (Trophectoderm) and PrE (Primative endoderm) Keywords: development dupicate analysis of time points
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8339 | biostudies-arrayexpress
UnknownTrophectoderm Transcriptome Analysis in LIN28 Knockdown Ovine Conceptuses Suggests Diverse Roles of the LIN28-let-7 Axis in Placental and Fetal Development.
Not available
S-EPMC8997724 | biostudies-literature
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