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GenomicsXEN state reprogramming into self-organizing trophectoderm-like cells enables the assembly of synthetic embryoids
XEN state reprogramming into self-organizing trophectoderm-like cells enables the assembly of synthetic embryoids
PRJNA670717 | ENA
GenomicsTrophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation [scRNA-seq]
Trophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation [scRNA-seq]
PRJNA1231500 | ENA
GenomicsTrophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation [bulk RNA-seq]
Trophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation [bulk RNA-seq]
PRJNA1231499 | ENA
GenomicsGenome-wide mapping of Eset-binding sites and H3K9me3 state in mouse embryonic stem cells
The histone H3 lysine 9 (H3K9) methyltransferase Eset is an epigenetic regulator critical for the development of the inner cell mass (ICM). Although ICM-derived embryonic stem (ES) cells are normally unable to contribute to the trophectoderm (TE) in blastocysts, we find that depletion of Eset by shR...
ORGANISM(S): Mus musculus 
2009-11-04 | E-GEOD-17642 | biostudies-arrayexpress
TranscriptomicsTrophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation [scRNA-seq]
Mouse extended pluripotent stem (EPS) cells have demonstrated significant potential for generating embryo models in vitro. However, their limited capacity for extraembryonic trophoblast development has hindered their use in constructing whole embryo models, particularly post-implantation embryoids. ...
ORGANISM(S): Mus musculus 
2025-10-21 | GSE291069 | GEO
TranscriptomicsXEN state reprogramming into self-organizing trophectoderm-like cells enables the assembly of synthetic embryoids
We established culture conditions that enable the two fates of blastocysts’ extraembryonic lineages – the primitive endoderm and the trophectoderm – to co-exist in a shared XTE state. The XTE cells exhibit robust self-organization capacity and in combination with ES cells enable the assembly of blas...
ORGANISM(S): Mus musculus 
2022-09-13 | GSE159883 | GEO
TranscriptomicsTrophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation [bulk RNA-seq]
Mouse extended pluripotent stem (EPS) cells have demonstrated significant potential for generating embryo models in vitro. However, their limited capacity for extraembryonic trophoblast development has hindered their use in constructing whole embryo models, particularly post-implantation embryoids. ...
ORGANISM(S): Mus musculus 
2025-10-21 | GSE291068 | GEO
UnknownHaploid-genetic screening of trophectoderm specification identifies Dyrk1a as a repressor of totipotent-like status.
Not available
S-EPMC10732524 | biostudies-literature
TranscriptomicsRNA-seq of XTE cells and vesicles, XEN and XEN-like cells, and ES cells
The conventional trophoblast stem cells represent post-implantation extraembryonic ectoderm-like state and not that of pre-implantation trophectoderm, irrespective of their origin. To capture the trophectoderm-like state we established culture conditions that facilitate the co-existence of character...
ORGANISM(S): Mus musculus 
2022-09-13 | E-MTAB-8788 | biostudies-arrayexpress
ProteomicsESRRB Facilitates the Conversion of Trophoblast-like Stem Cells from Induced Pluripotent Stem cells by Directly Regulating KRT8 and CDX2
Porcine induced pluripotent stem cells (piPSCs) could serve as a great model system for human stem cell pre-clinical research. However, the pluripotency gene network of piPSCs, especially the function for the core transcription factor ESRRB, was poorly understood. Here, we constructed ESRRB-overexpr...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-02-17 | PXD027539 | Pride
Trophoblast stem cells (tscs) Esrrb Induced pluripotent stem cells (ipscs) Cdx2 Krt8 
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