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MetabolomicsChemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation

Background: Placental metabolic abnormalities are linked to pregnancy complications such as preeclampsia, gestational diabetes mellitus and fetal growth restriction. However, little is known about how the metabolic processes regulate placental development and trophoblast differentiation. The adip...

2025-06-13 | MTBLS12552 | MetaboLights
TranscriptomicsEffect of Leptin on Mouse Trophoblast Giant Cells
Leptin, a hormone produced primarily by adipose tissue, plays a role in both energy homeostasis and reproduction, and is required in early pregnancy. Leptin stimulates metalloproteinase activity in cultured human trophoblast and stimulates invasiveness of cultured mouse trophoblast. The goal of th...
ORGANISM(S): Mus musculus 
2010-10-08 | E-GEOD-10297 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human endometrial stromal cells treated with human trophoblasts vs. control, sampled at multiple time points to investigate stromal cell response to paracrine signals from the trophoblast
During the invasive phase of implantation, trophoblasts and maternal decidual stromal cells secrete products that regulate trophoblast differentiation and migration into the maternal endometrium. Paracrine interactions between the extravillous trophoblast and the maternal decidua are important for s...
ORGANISM(S): Homo sapiens 
2007-11-02 | E-GEOD-5809 | biostudies-arrayexpress
ProteomicsProteomics of a microphysiological model of human trophoblast invasion during early embryo implantation
We have designed an implantation-on-a-chip device to model the invasion of specialized fetal extravillous trophoblasts (EVTs) from an implanting embryo into the maternal decidua. We profiled the proteome of the external factors secreted in the model, containing different cell population compositions...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-16 | MSV000086888 | MassIVE
TranscriptomicsGene expression profiles of trophoblast cell lines
Invasive extravillous trophoblasts (EVTs) of the human placenta are critically involved in successful pregnancy outcome since they remodel the uterine spiral arteries to increase blood flow and oxygen delivery to the placenta and the developing fetus. To gain more insights into their biological role...
ORGANISM(S): Homo sapiens 
2010-09-23 | E-GEOD-20510 | biostudies-arrayexpress
TranscriptomicsSharkey trophoblast
Transcriptional profiling comparison of human primary villous trophoblast and extra-villous trophoblast (VT and EVT respectively) cells, isolated from the placenta at 8 to 12 weeks gestation, with complimentary transcriptional profiling of choriocarcinoma cell lines JEG-3 and JAR. Based on phenotypi...
ORGANISM(S): Homo sapiens 
2011-04-28 | E-MTAB-429 | biostudies-arrayexpress
TranscriptomicsConditional knockout of Sox2 in embryonic and trophoblast stem cells.
To compare the transcriptional networks governed by Sox2 in embryonic stem (ES) cells and trophoblast stem (TS) cells, we performed whole-genome expression analysis after tetracycline (Tet)-induced knockout of Sox2 in each cell type. A Tet-inducible Sox2 knockout ES cell line 2TS22C or its derivativ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-28451 | biostudies-arrayexpress
GenomicsSox2-regulatory networks in embryonic and trophoblast stem cells.
Sox2 is a pleiotropic transcription factor that regulates self-renewal and differentiation capacity in different types of stem cells, raising the possibility that it regulates similar transcriptional programs controlling common stemness. Embryonic stem (ES) cells and trophoblast stem (TS) cells are ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-28455 | biostudies-arrayexpress
TranscriptomicsGata3 acts alongside Cdx2 to promote trophoblast gene expression downstream of Tead4 during mouse development
The first lineage decisions during mouse development lead to establishment of embryonic and extraembryonic tissues. The transcription factor Cdx2 plays a central role by repressing pluripotency genes, such as Oct4 and promoting trophoblast fate at the blastocyst stage. Here we show that the transcri...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12999 | biostudies-arrayexpress
GenomicsConversion of Fibroblasts into Functional Trophoblast Stem-like Cells
Here we demonstrate the generation of stable induced trophoblast stem cells (iTSCs) from fibroblasts by the transient expression of Gata3, Eomes and Tfap2c. Transcriptome and methylome analyses and functional assays such as hemorrhagic lesion formation and placenta contribution suggested a high deg...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-70234 | biostudies-arrayexpress
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