Trophoblast stem cells

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Organisms

Homo sapiens (266)
Mus musculus (247)
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Macaca fascicularis (2)
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Repository

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pride (22)
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Tissue

Embryonic stem cell (7)
Stem cell (6)
Cell culture (5)
Embryo (5)
Trophoblast cell (3)
Fibroblast (2)
Placental villous trophoblast (2)
Trophoblast (2)
Blood serum (1)
Early embryonic cell (1)
Epithelial cell (1)
Extravillous trophoblast (1)
Placenta (1)
Syncytiotrophoblast cell (1)
Testis (1)
Trophoblast stem cell (1)

Disease

Normal (2)
Disease free (2)
Mild asthma (1)
Not Applicable (1)
HCMV infected (primary) (1)
Zika virus congenital syndrome (1)

Technology Type

Mass Spectrometry (22)
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Mass spectrometry (1)
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Instrument Platform

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Publication Date

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2016 (47)
2020 (34)
2019 (30)
2017 (30)
2008 (29)
2018 (25)
2009 (17)
2005 (8)
2007 (5)
2006 (3)

Metabolite Name

GlcADG 37:5; GlcADG(15:0/22:5) (1)
MGDG 32:1; MGDG(17:0/15:1) (1)
PG 37:3; PG(18:1/19:2) (1)
PG 37:4; PG(18:2/19:2) (1)
PA 42:4; PA(22:0/20:4) (1)
PG 35:1; PG(16:0/19:1) (1)
MGDG 30:0; MGDG(15:0/15:0) (1)
MGDG 30:1; MGDG(15:0/15:1) (1)
LysoPI 24:1; LysoPI 24:1 (1)
PG 29:0; PG(10:0/19:0) (1)
PG 29:0; PG(14:0/15:0) (1)
MGDG 24:0; MGDG(8:0/16:0) (1)
PG 29:1; PG(11:0/18:1) (1)
GlcADG 26:0; GlcADG(12:0/14:0) (1)
PG 27:0; PG(12:0/15:0) (1)
Cer[BDS] 35:0; Cer[BDS](d18:0/17:0) (1)
PG 25:0; PG(10:0/15:0) (1)
FAHFA 40:4; FAHFA(18:1/22:3) (1)
FAHFA 40:5; FAHFA(18:2/22:3) (1)
LysoPI 18:0; LysoPI 18:0 (1)
FAHFA 38:0; FAHFA(19:0/19:0) (1)
FAHFA 38:3; FAHFA(16:0/22:3) (1)
Cer[NDS] 33:0; Cer[NDS](d17:0/16:0) (1)
FAHFA 37:3; FAHFA(15:0/22:3) (1)
Cer[NDS] 32:0; Cer[NDS](d17:0/15:0) (1)
FAHFA 36:1; FAHFA(18:1/18:0) (1)
FAHFA 36:3; FAHFA(18:2/18:1) (1)
PG 20:0; PG(10:0/10:0) (1)
FAHFA 35:0; FAHFA(15:0/20:0) (1)
PG 20:1; PG(2:0/18:1) (1)

First Public Date

2023 (99)
2026 (78)
2025 (78)
2022 (73)
2024 (63)
2014 (56)
2021 (54)
2020 (35)
2019 (35)
2017 (29)
2018 (17)
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2015 (13)
2013 (13)

Study type

Transcription profiling by array (337)
RNA-seq of coding RNA (72)
ChIP-seq (29)
RNA-seq of coding RNA from single cells (14)
Methylation profiling by array (11)
Other (9)
Methylation profiling by high throughput sequencing (6)
RNA-seq of total RNA (6)
Unknown experiment type (5)
Comparative genomic hybridization by array (5)
RNA-seq of non coding RNA (5)
ChIP-chip by tiling array (4)
Cell line - High-throughput sequencing (4)
Transcription profiling by RT-PCR (4)
Human - One-color microarray (3)
ATAC-seq (3)
Single nucleus RNA sequencing (2)
MeDIP-seq (1)
Human - High-throughput sequencing (1)
Translation profiling (1)
Animal - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
ChIP-chip by array (1)
Genotyping by array (1)
MicroRNA profiling by high throughput sequencing (1)
Bisulfite-seq (1)
Hi-C (1)
MicroRNA profiling by array (1)
Genotyping by high throughput sequencing (1)

Release Date

2015 (93)
2014 (87)
2013 (80)
2012 (78)
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2023 (63)
2011 (63)
2010 (61)
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2016 (58)
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2024 (53)
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2018 (37)
2008 (33)
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2009 (24)
2026 (16)
2007 (7)
2006 (6)
2005 (6)
2003 (1)
2002 (1)
1999 (1)

Lab affiliation

Babraham Institute Cambridge UK (2)
Associate Professor Regional Centre for Biotechnology (1)
Baker Heart & Diabetes Inst. (1)
Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstrasse 17, A-1090 Vienna, Austria Tel.: +4314016037718 (1)
Centro de Biología Molecular (CBM) (1)
College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China (1)
Department of Genome Regulation, Max Planck Institute for Molecular Genetics; Berlin, Germany (1)
Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands (1)
Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, CA 94143, USA Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA Department of Anatomy, University of California, San Francisco, CA 94143, USA (1)
Edward M. Marcotte, PhD Center for Systems and Synthetic Biology Department of Molecular Biosciences University of Texas at Austin 2500 Speedway, MBB 3.148BA Austin, TX 78712-0159 (1)
Harvard Department of Stem Cell and Regenerative Biology Cambridge, MA 02138, USA (1)
InnoHK Centre for Translational Stem Cell Biology, The University of Hong Kong (1)
Max Planck Institute for Molecular Genetics Department of Genome Regulation Ihnestraße 63-73 14195 Berlin, Germany (1)
Max Planck Institute for Molecular Genetics, Berlin, Germany (1)
Max Plank Institute for Molecular Genetics (1)
Max-Planck-Institut für molekulare Genetik Aydan Bulut-Karslioglu, PhD Ihnestraße 63-73 14195 Berlin, Germany (1)
ProGenTomics, Laboratory of Pharmaceutical Biotechnology, Ghent University, B-9000 Ghent, Belgium (1)
Raymond H. Wittcoff Distinguished Professor and Head Department of Biochemistry and Molecular Biophysics Washington University School of Medicine St. Louis, MO 63110 (1)
Tohoku University Graduate School of Medicine (1)
University of Edinburgh (1)
University of Wiscosin Madison Wisconsin National Primate Research Center (1)

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Sox2-regulatory networks in embryonic and trophoblast stem cells.

Sox2 is a pleiotropic transcription factor that regulates self-renewal and differentiation capacity in different types of stem cells, raising the possibility that it regulates similar transcriptional programs controlling common stemness. Embryonic stem (ES) cells and trophoblast stem (TS) cells are ...

ORGANISM(S): Mus musculus

2013-10-17 | E-GEOD-28455 | biostudies-arrayexpress

Conditional knockout of Sox2 in embryonic and trophoblast stem cells.

To compare the transcriptional networks governed by Sox2 in embryonic stem (ES) cells and trophoblast stem (TS) cells, we performed whole-genome expression analysis after tetracycline (Tet)-induced knockout of Sox2 in each cell type. A Tet-inducible Sox2 knockout ES cell line 2TS22C or its derivativ...

ORGANISM(S): Mus musculus

2013-10-17 | E-GEOD-28451 | biostudies-arrayexpress

Dynamics of Sox2 occupancy during the differentiation of embryonic stem cells into trophoblast stem cells.

To understand the mechanism underlying the versatility in transcriptional regulation by Sox2, we compared genome-wide binding sites of Sox2 in embryonic stem (ES) cells and trophoblast stem (TS) cells by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq). A tetracycline-...

ORGANISM(S): Mus musculus

2013-10-17 | E-GEOD-28453 | biostudies-arrayexpress

Conversion of Fibroblasts into Functional Trophoblast Stem-like Cells

Here we demonstrate the generation of stable induced trophoblast stem cells (iTSCs) from fibroblasts by the transient expression of Gata3, Eomes and Tfap2c. Transcriptome and methylome analyses and functional assays such as hemorrhagic lesion formation and placenta contribution suggested a high deg...

ORGANISM(S): Mus musculus

2016-07-05 | E-GEOD-70234 | biostudies-arrayexpress

Induction of trophoblast stem cells from embryonic stem cells by forced repression of Oct3/4.

To characterize the transdifferentiation of embryonic stem (ES) cells into trophoblast stem (TS) cells triggered by forced repression of Oct3/4, we performed whole-genome expression analysis after tetracycline (Tet)-induced knockout of Oct3/4. A Tet-inducible Oct3/4 knockout ES cell line ZHBTc4 was ...

ORGANISM(S): Mus musculus

2013-10-17 | E-GEOD-28452 | biostudies-arrayexpress

ESRRB Facilitates the Conversion of Trophoblast-like Stem Cells from Induced Pluripotent Stem cells by Directly Regulating KRT8 and CDX2

Porcine induced pluripotent stem cells (piPSCs) could serve as a great model system for human stem cell pre-clinical research. However, the pluripotency gene network of piPSCs, especially the function for the core transcription factor ESRRB, was poorly understood. Here, we constructed ESRRB-overexpr...

ORGANISM(S): Sus scrofa domesticus (domestic pig)

2022-02-17 | PXD027539 | Pride

Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas

The goal of the present study was to characterize HLA-G-positive cells derived from human embryonic stem cells treated with BMP4 for five days and compare them to HLA-G positive cells derived from human first trimester placentas Human embryonic stem cells were cultured with BMP4 in the absence of F...

ORGANISM(S): Homo sapiens

2013-05-02 | E-GEOD-42112 | biostudies-arrayexpress

Marmoset and human trophoblast stem cells differ in signaling requirements and recapitulate divergent modes of trophoblast invasion.

Not available

S-EPMC7616712 | biostudies-literature

Transcription profiling of placental trophoblast stem cells time dependent response to hyperosmolar stress

Stress induces undifferentiated stem cells to differentiate in a way that looks like normal differentiation; We used hyperosmolar stress as a generic, energy-depleting stressor and tested for the global changes in the transcriptional response of placental trophoblast stem cells Experiment Overall De...

ORGANISM(S): Mus musculus

2008-11-13 | E-GEOD-9519 | biostudies-arrayexpress

Isolation and Characterisation of a Novel Trophoblast Hoescht Side-Population with Stem Cell Properties from First Trimester Placentae

In this work, we have isolated a Hoescht side-population of trophoblasts from first trimester human placentae that cluster separately from more differentiated trophoblast populations, and have a transcriptomic profile indicative of a stem cell population. Hoescht side-population cells were compared ...

ORGANISM(S): Homo sapiens

2015-11-03 | E-GEOD-57834 | biostudies-arrayexpress

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