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TranscriptomicsSequencing of small RNA libraries prepared from Invertebrate Iridescent Virus 6 (IIV6)-infected S2 cells or adult flies.
We observed several hundreds of thousand reads matching the IIV6 genome in IIV6 infected S2 and wild-type flies. The large majority of these reads have a size of 21 nt. This peak was absent from the library prepared from S2 non-infected and infected Dcr-2-/- mutant flies. The virus-derived siRNAs we...
ORGANISM(S): Invertebrate iridescent virus 6 
2013-02-06 | E-GEOD-41007 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila infected with Drosophila C virus reveals a third evolutionary conserved innate immunity pathway operates in drosophila and counters viral infection
The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate NF-kB family members. We have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct fr...
ORGANISM(S): Drosophila melanogaster 
2007-07-07 | E-GEOD-2828 | biostudies-arrayexpress
TranscriptomicsAnalysis of genes regulated by Akirin and Brahma upon IMD pathway activation in drosophila S2 cells
This micro-array helps establishing the function of Akirin, a nuclear protein with unknown domains, a putative interacting partner, in the transcriptional regulation of the targets of Relish, a NF-kB factor required to fight Gram(-) bacteria infection in Drosophila melanogaster. S2 cells were knocke...
ORGANISM(S): Drosophila melanogaster 
2014-11-05 | E-GEOD-54915 | biostudies-arrayexpress
TranscriptomicsThe cytokine DIEDEL and a viral homologue suppress deleterious IMD-dependent gene expression in drosophila
Viral infection in Drosophila triggers inducible gene expression, but the function of many of these genes and the biological significance of their induction remain poorly understood. Here, we report the functional characterization of the gene Diedel, which is strongly induced following some viral in...
ORGANISM(S): Drosophila melanogaster 
2016-01-07 | E-GEOD-68174 | biostudies-arrayexpress
UnknownPreexposure prophylaxis for HIV infection among African women.
Not available
S-EPMC3687217 | biostudies-literature
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