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To gain insight into the host cell types, cellular and molecular pathways possibly involved in the differential permissiveness to pulmonary replication of M. tuberculosis, we carried out transcript profiling studies on M. tuberculosis-infected lungs from congenic and parental strains. We were partic...
ORGANISM(S): Mus musculus 
B6 mice have been infected via the aerosol route with a low-dose (100 CFUs)of Mycobacterium tuberculosis for 30 days and 70 days.

Uninfected mice have been used as experimental controls.
ORGANISM(S): Mus musculus 
This phase I/II neoadjuvant trial determined maximally-tolerated doses (MTD), dose-limiting toxicities (DLT), response-to-therapy, and explored the role of new response biomarkers. The combination regimens were delivered with acceptable toxicity, good clinical response, inducing changes in tumor RNA...
ORGANISM(S): Homo sapiens 
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