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GenomicsElevated Nrf2 response in TrxR1/Gsr-null livers
Elevated Nrf2 response in TrxR1/Gsr-null livers
PRJNA512023 | ENA
ProteomicsDual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation (2)
Copper (Cu) performs essential structural and functional roles in all aerobic organisms, but identifying natural cuproproteins through traditional affinity methods is hindered by the variety of copper ligand combinations and binding locations in proteins. Here, using ATOX1 as a bait, fused with the ...
ORGANISM(S): Homo Sapiens 
2025-09-22 | PXD068649 |
ProteomicsDual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation (1)
Copper (Cu) performs essential structural and functional roles in all aerobic organisms, but identifying natural cuproproteins through traditional affinity methods is hindered by the variety of copper ligand combinations and binding locations in proteins. Here, using ATOX1 as a bait, fused with the ...
ORGANISM(S): Homo Sapiens 
2025-09-22 | PXD068622 |
TranscriptomicsElevated Nrf2 response in TrxR1/Gsr-null livers
Liver-specific depletion of both of the cytosolic NADPH-dependent disulfide reductases, TrxR1 and Gsr, was shown to result in increased activation of Nrf2 as compared to elimination of either of these enzymes alone. Activation of transcription factor Nrf2 and its downstream cytoprotective target gen...
ORGANISM(S): Mus musculus 
2019-05-01 | GSE124445 | GEO
UnknownTrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
Not available
S-EPMC6561278 | biostudies-literature
GenomicsTargeting Thioredoxin Reductase 1 (TrxR1) Uncovers Ferroptosis-Linked Transcriptional Vulnerabilities in Lung Cancer
Targeting Thioredoxin Reductase 1 (TrxR1) Uncovers Ferroptosis-Linked Transcriptional Vulnerabilities in Lung Cancer
PRJNA1280173 | ENA
UnknownMiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation.
Not available
S-EPMC5543121 | biostudies-literature
UnknownIrreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.
Not available
S-EPMC7083616 | biostudies-literature
UnknownTIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport.
Not available
S-EPMC5364507 | biostudies-literature
UnknownTrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-кβ inhibition.
Not available
S-EPMC5056617 | biostudies-literature
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