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MetabolomicsAssociation between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease

Chagas disease causes a cardiac illness characterized by immunoinflammatory reactions leading to myocardial fibrosis and remodeling. The development of Chronic Chagas Cardiomyopathy (CCC) in some patients while others remain asymptomatic is not fully understood, but dysregulated inflammatory resp...

2024-01-11 | MTBLS8390 | MetaboLights
ProteomicsProteomic characterization of the cellular effects of AHR activation by microbial tryptophan catabolites in endotoxin-activated human macrophages
Sensing of microbial tryptophan catabolites by the aryl hydrocarbon receptor (AhR) plays a pivotal role in host-microbiome homeostasis by modulating the host immune response. Thereby the involved cellular processes triggered by the metabolites are largely unknown. We analyzed proteomic changes in ma...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025022 | Pride
Metabolism Lipopolysaccharides Proteomics Tmt Tryptophan catabolites Benzo[a]pyrene Indole-3-aldehyde Ahr Indole-3-acetic acide Human macrophages Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse MBP Ac 11-11 activated purified CD4+ T cells
Local catabolism of the amino acid tryptophan (Trp) by indoleamine-2,3-dioxygenase (IDO) is considered an important mechanism of regulating T cell immunity. We show that IDO transcription was increased upon stimulation of myelin-specific T cells with tolerogenic altered self-peptides. Catabolites of...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3401 | biostudies-arrayexpress
ProteomicsProfiling Tryptophan Catabolites of Human Gut Microbiota and Acute-Phase Protein Levels in Neonatal Dried Blood Specimens
National screening programs use dried blood specimens to detect abnormal metabolism or aberrant protein function in infants shortly after birth, thus identifying disorders that are not clinically evident in the newborn period. Gut microbiota metabolites and immunological acute phase proteins are cap...
ORGANISM(S): Homo Sapiens 
2022-08-02 | PXD027606 | panorama
GenomicsMicrobiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer II
Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer II
PRJNA831811 | ENA
GenomicsMicrobiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer III
Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer III
PRJNA831823 | ENA
GenomicsMicrobiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer I
Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer I
PRJNA831812 | ENA
UnknownGut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization.
Not available
S-EPMC7177849 | biostudies-literature
UnknownSimultaneous determination of tryptophan and its 31 catabolites in mouse tissues by polarity switching UHPLC-SRM-MS.
Not available
S-EPMC6224157 | biostudies-literature
UnknownImpact of High-Fiber or High-Protein Diet on the Capacity of Human Gut Microbiota To Produce Tryptophan Catabolites.
Not available
S-EPMC10176579 | biostudies-literature
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