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MetabolomicsAssociation between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease

Chagas disease causes a cardiac illness characterized by immunoinflammatory reactions leading to myocardial fibrosis and remodeling. The development of Chronic Chagas Cardiomyopathy (CCC) in some patients while others remain asymptomatic is not fully understood, but dysregulated inflammatory resp...

2024-01-11 | MTBLS8390 | MetaboLights
MetabolomicsMicrobiota network modules-derived tryptophan metabolites improve cognition via microglial AhR/Sirpα signaling

Gut microbiota dysbiosis has emerged as one of the hallmarks of aging, highlighting the need to identify microbial network modules as new biomarkers rooted in microbiota interactions and develop targeted nutritional interventions. The current research, integrating data from Alzheimer's disease (A...

2026-08-08 | MTBLS12508 | MetaboLights
MetabolomicsMicrobiota network modules-derived tryptophan metabolites improve cognition via microglial AhR/Sirpα signaling
Gut microbiota dysbiosis has emerged as one of the hallmarks of aging, highlighting the need to identify microbial network modules as new biomarkers rooted in microbiota interactions and develop targeted nutritional interventions. The current research, integrating data from Alzheimer's disease (AD) ...
2026-08-07 | MTBLS15265 | MetaboLights
MetabolomicsMicrobiota network modules-derived tryptophan metabolites improve cognition via microglial AhR/Sirpα signaling

Gut microbiota dysbiosis has emerged as one of the hallmarks of aging, highlighting the need to identify microbial network modules as new biomarkers rooted in microbiota interactions and develop targeted nutritional interventions. The current research, integrating data from Alzheimer's disease (A...

2026-08-08 | MTBLS12506 | MetaboLights
MetabolomicsTryptophan Metabolism and AHR Signaling in the Intraocular Fluid of Uveitis: An Exploratory Study Integrating Metabolomics, Single-Cell Transcriptomics, Molecular Docking, and Mendelian Randomization within a Gut–Eye Axis Framework
Uveitis is a highly heterogeneous intraocular inflammatory disease, and recurrent attacks can lead to irreversible visual impairment. Gut microbiota may contribute to its pathogenesis through metabolic products and immune modulation, but existing evidence is largely derived from cross-sectional asso...
2026-08-28 | MTBLS15487 | MetaboLights
ProteomicsTryptophan depletion provokes the production and presentation of in-frame tryptophan to phenylalanine substitutions
Activated T cells secrete interferon-gamma (IFN) that triggers an intra-cellular tryptophan shortage through the activation of the Indoleamine 2,3-Dioxygenase 1 (IDO1) enzyme. Surprisingly, we here show that despite tryptophan depletion, in-frame protein synthesis bypassing tryptophan codons contin...
ORGANISM(S): Homo sapiens (Human) 
2021-12-23 | PXD028921 | Pride
Cancer Tryptophan depletion Amino acid substitution Lc-ms/ms 
MetabolomicsBupleurum chinense DC polysaccharides ameliorate DSS-induced ulcerative colitis by regulating gut microbiota and tryptophan metabolism via NF-κB pathway

Background: Bupleurum chinense DC polysaccharide (BCP) demonstrates a significant role in ameliorating gastric ulceration and enhancing intestinal barrier function, and have broad medicinal value. Nevertheless, the therapeutic effects and mechanisms in ulcerative colitis (UC) remain to be elucida...

2026-02-01 | MTBLS13814 | MetaboLights
TranscriptomicsTranscription profiling of mouse MBP Ac 11-11 activated purified CD4+ T cells
Local catabolism of the amino acid tryptophan (Trp) by indoleamine-2,3-dioxygenase (IDO) is considered an important mechanism of regulating T cell immunity. We show that IDO transcription was increased upon stimulation of myelin-specific T cells with tolerogenic altered self-peptides. Catabolites of...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3401 | biostudies-arrayexpress
UnknownEndogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback.
Not available
S-EPMC10331327 | biostudies-literature
UnknownThe structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase.
Not available
S-EPMC7529051 | biostudies-literature
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