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TranscriptomicsOpen lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage
Introduction: The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 mL/kg) tidal volume (VT) ventilation with open lung positive end-expiratory pressure set ...
ORGANISM(S): Rattus norvegicus 
2014-04-24 | E-GEOD-52142 | biostudies-arrayexpress
TranscriptomicsSarcolipin is a potential biomarker for dystrophy and is involved in inflammatory processes in skeletal muscles
Myopathies and muscular dystrophies are devastating diseases sharing characteristic symp-toms. Little is known about common aetiopathology and biomarkers are rare. We studied skeletal muscle gene expression in mouse models of myopathies. As dystrophic processes in muscles are characterised by infl...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-33157 | biostudies-arrayexpress
TranscriptomicsThe expression of inflammatory genes in endothelial cells is inhibited by N-octanoyl dopamine via modulation of the NFkB pathway
Background: Dopamine has intrinsic receptor-independent anti-inflammatory properties when used at high concentrations. Since cellular uptake of N-octanoyl dopamine (NOD) is far better than of dopamine, NOD might display anti-inflammatory effects already at relative low concentrations. The present st...
ORGANISM(S): Homo sapiens 
2012-08-30 | E-GEOD-34059 | biostudies-arrayexpress
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