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TranscriptomicsThe TSC/mTOR pathway regulates the innate inflammatory response
The TSC/mTOR (tuberous sclerosis complex/mammalian target of rapamycin) pathway has a central role in cell growth and is involved in human tumorigenesis. Here, we demonstrate an unexpected role of TSC2 and mTOR in regulating key inflammatory cytokines in monocytes, macrophages, and dendritic cells a...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-6002 | biostudies-arrayexpress
TranscriptomicsPromoter Capture Hi-C of mouse ESC and TSC
Chromatin organisation of trophoblast stem cells (TSC) were compared with that of embryonic stem cells (ESC). The method enriches Hi-C libraries, to detect promoter interactions at restriction fragment level. We prepared Hi-C libraries from TSC and ESC (serum grown) samples and enriched them with a ...
ORGANISM(S): Mus musculus 
2018-09-05 | E-MTAB-6585 | biostudies-arrayexpress
TranscriptomicsPlacental PPARg-Regulated Genes
Robust identification of placental PPARg target genes via mutliple PPARg-dependence criteria. Integration of differential expression data from Pparg-null, Rxra-null, Med1-nul and Ncoa6-null placentas and from WT and Pparg-null Trophoblast stem cells (TSC) differentiated for 2 or 4 days in the presen...
ORGANISM(S): Mus musculus 
2012-07-09 | E-GEOD-39233 | biostudies-arrayexpress
GenomicsEOMES safeguards TSC chromatin accessibility by directing BRG1 to TSC-associated loci [RNA-seq]
EOMES safeguards TSC chromatin accessibility by directing BRG1 to TSC-associated loci [RNA-seq]
PRJNA1156180 | ENA
GenomicsEOMES safeguards TSC chromatin accessibility by directing BRG1 to TSC-associated loci [CUT&RUN]
EOMES safeguards TSC chromatin accessibility by directing BRG1 to TSC-associated loci [CUT&RUN]
PRJNA1154558 | ENA
GenomicsEOMES safeguards TSC chromatin accessibility by directing BRG1 to TSC-associated loci [ATAC-seq]
EOMES safeguards TSC chromatin accessibility by directing BRG1 to TSC-associated loci [ATAC-seq]
PRJNA1154562 | ENA
GenomicThe Genomic Landscape of Tuberous Sclerosis Complex (TSC)

In this study, we characterized the genomic landscape of tuberous sclerosis complex (TSC), a rare genetic disease causing multisystem growth of benign tumors and other hamartomatous lesions. We analyzed 127 human tissues, including 111 TSC-associated samples and 16 non-TSC negative controls, usin...

phs001357 | dbGaP
ModelsDallePezze2012 - TSC-independent mTORC2 regulation
DallePezze2012 - TSC-independent mTORC2 regulation This model is described in the article: A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation. Dalle Pezze P, Sonntag AG, Thien A, Prentzell MT, Gödel M, Fischer S, Neumann-Haefelin E, Huber TB, B...
2024-09-02 | BIOMD0000000581 | BioModels
TranscriptomicsA survey of imprinted gene expression in mouse trophoblast stem cells
Several hundred mammalian genes are expressed preferentially from one parental allele due to a process called genomic imprinting. Genomic imprinting is particularly prevalent in extra-embryonic tissue, where it plays an essential role during development. Here, we profiled imprinted gene expression v...
ORGANISM(S): Mus musculus 
2015-02-24 | E-GEOD-63968 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human uberous sclerosis complex (TSC) Tumor Fibroblasts
Patients with tuberous sclerosis complex (TSC) develop hamartomas containing biallelic inactivating mutations in either TSC1 or TSC2, resulting in mammalian target of rapamycin (mTOR) activation. Hamartomas overgrow epithelial and mesenchymal cells in TSC skin. The pathogenetic mechanisms for these ...
ORGANISM(S): Homo sapiens 
2008-04-06 | E-GEOD-9715 | biostudies-arrayexpress
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