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Transcriptomicsp53 reactivation in liver tumors
We induced liver tumors by transforming liver progenitor cells (LPC) with retroviruses expressing oncogenic Ras coupled to tetracycline transactivator together with an inducible shRNA targeting p53. Transformed LPCs were orthotopical transplanted into recipient livers and after tumor onset mice wer...
ORGANISM(S): Mus musculus 
2013-11-11 | E-GEOD-52091 | biostudies-arrayexpress
TranscriptomicsExpression data from proliferating and senescent murine hepatic stellate cells
The p53 protein is a cell-autonomous tumor suppressor that restricts malignant transformation by triggering cell cycle exit or apoptosis. p53 also promotes cellular senescence, a program that triggers a stable cell cycle arrest and can modify the tissue microenvironment through its effect on cell me...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-39469 | biostudies-arrayexpress
TranscriptomicsYAP Inhibition in HCC cells (Hep3B)
siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA. Loss of contact inhibition and anchorage-independent growth are hallmarks of cancer cells. In this context, frequent inactivation of the Hippo pathway and subsequent nuclear enrichment of the transcripti...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-35004 | biostudies-arrayexpress
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