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TranscriptomicsExpansion of HSC by AML1a
Mouse bone marrow cells were infected with retrovirus for doxycylin-controllable AML1a expression, and cultured in vitro. Cells were treated with doxycycline to silence AML1a expression or left untreated to keep AML1a expression on, and subjected to microarray analysis to profile transcripts AML1a i...
ORGANISM(S): Mus musculus 
2011-12-19 | E-MEXP-3179 | biostudies-arrayexpress
TranscriptomicsPromotion and maintenance of leukemia by ERG Thymocytes No.2
Thymocytes from mice transplanted with bone marrow cells infected with retrivirus for ERG were compared with control thymocytes regarding to gene expression. Mutations in Notch1 gene were not detected in the thymocytes.
ORGANISM(S): Mus musculus 
2011-04-16 | E-MEXP-2988 | biostudies-arrayexpress
TranscriptomicsPromotion and maintenance of leukemia by ERG No.1
Thymocytes without mutation in Notch1 in mice transplanted with ERG-transduced BM cells were compared with thymocytes in mice transplanted with GFP control-transduced bone marrow cells.
ORGANISM(S): Mus musculus 
2011-04-16 | E-MEXP-2986 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human leukemia cell lines, MHH-CALL-4 and MUTZ-5, treated either with Ruxolitinib, FX1, or their combination.
CRLF2-rearranged acute lymphoblastic leukemia (ALL) is associated with poor clinical outcomes. Although JAK1/2 is activated in this type of ALL, treatment with JAK1/2 inhibitors is insufficient in inhibiting cell growth and inducing apoptosis. BCL6 upregulation upon JAK inhibition may account for th...
ORGANISM(S): Homo sapiens 
2022-07-31 | E-MTAB-10755 | biostudies-arrayexpress
TranscriptomicsComprehensive gene expression profiles of NK cell neoplasms identify vorinostat as an effective drug candidate
Transcriptional profiling of NK cell lines (NKL & NKYS) with DMSO or vorinostat
ORGANISM(S): Homo sapiens 
2013-01-24 | E-MTAB-1410 | biostudies-arrayexpress
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