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TranscriptomicsHierarchical synergy of Pten, p53 and Rb pathways in high-grade astrocytoma induced in adult brain
Mutations in the PTEN, TP53 and RB1 pathways are obligate events in the pathogenesis of human glioblastomas, the highest grade of astrocytoma. To investigate synergy between these tumor suppressors in mice, we induced various combinations of compound deletions conditionally in astrocytes and neural ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-22927 | biostudies-arrayexpress
UnknownGenotype-Guided Dosing of Warfarin in Chinese Adults: A Multicenter Randomized Clinical Trial.
Not available
S-EPMC7439928 | biostudies-literature
TranscriptomicsNovel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
The outcome for children with high-grade gliomas (HGG) remains dismal, with a two-year survival rate of only 10-30%. Approximately half of pediatric HGGs are diffuse intrinsic pontine glioma (DIPG), a brainstem tumor that arises almost exclusively in children. Genome-wide analyses of copy number i...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-46190 | biostudies-arrayexpress
ProteomicsSecreted protein of Pasteurella multocidaP201902194-P20191001818
Bovine Pasteurella multocida (P. multocida) serotype A is considered to be one of the major causes of bovine respiratory disease (BRD), while its secretory proteins remain poorly understood. In this study, we employed data-independent acquisition (DIA) LC-MS/MS combined with bioinformatics analysis ...
ORGANISM(S): Pasteurella Multocida Subsp. Multocida Str. Anand1_cattle 
2022-11-02 | PXD037882 |
TranscriptomicsTranscription profiling of human hematopoietic stem cells engrafted into fetal goats
Robust human-goat chimerism was achieved by transplanting human CD34+Lin- cord blood cells into fetal goats. We observed a broad distribution of GFP-marked human cells in non-hematopoietic organs including kidney, muscle, lung, and heart of transplant goats. Various marker techniques indicated that...
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-1801 | biostudies-arrayexpress
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