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ProteomicsPPARs and c-Myc regulate metabolism of renal tubules
Different segments of renal tubules have distinct metabolic features and functions, and defective metabolism in renal tubules is involved in the pathobiology of kidney diseases. However, the mechanisms underlying the metabolic regulation in renal tubules remain to be defined. We demonstrated that th...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-15 | PXD007828 | Pride
Pparγ  ppar  c-myc  nrf2  lipid metabolism  glycolysis  renal proximal tubules  renal distal tubules  kidney 
TranscriptomicsTranscription profiling of rat seminiferous tubules, purifed germ cells and sertoli cells
Mammalian spermatogenesis is a complex biological process that occurs within a highly organized tissue, the seminiferous epithelium. The coordinated maturation of spermatogonia, spermatocytes and spermatids suggests the existence of precise programs of gene expression in these cells as well as in t...
ORGANISM(S): Rattus norvegicus 
2008-06-20 | E-GEOD-8978 | biostudies-arrayexpress
TranscriptomicsMalpigian tubules
modENCODE_submission_5521 This submission comes from a modENCODE project of David MacAlpine. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: Most terminally differentiated Drosophila tissues are either polyploid or polytene. Unlike normal chromosomes, where th...
ORGANISM(S): Drosophila melanogaster 
2012-06-03 | E-GEOD-38439 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat kidney tubules infected with uropathogenic E. coli to study early local bacterial inflammation
The transcriptome of early local kidney inflammation was profiled. Rat kidney tubules were injected with uropathogenic E. coli or PBS control. After incubation time, kidney samples were processed and transcription was assayed. Three rats were used per condition.
ORGANISM(S): Rattus norvegicus 
2010-04-14 | E-MEXP-2136 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Clcn5 knockout in proximal tubules of the kidney
Dent disease has multiple defects attributed to proximal tubule malfunction including low molecular weight proteinuria, aminoaciduria, phosphaturia and glycosuria. In order to understand the changes in kidney function of the Clc5 transporter gene knockout mouse model of Dent disease, we examined gen...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10162 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila pooled Malpighian tubules vs. whole fly
This is an affymetrix array experiment comparing the transcriptome of the Malpighian tubule (or renal tubule) of 7-day adult Oregon R strain Drosophila melanogaster with matched whole fly samples. It is described in:,Wang, J., Kean, L., Yang, J., Allan, A. K., Davies, S. A., Herzyk, P. and Dow, J. A...
ORGANISM(S): Drosophila melanogaster 
2007-07-06 | E-GEOD-1690 | biostudies-arrayexpress
ProteomicsShotgun proteomics analysis of single human tubules
We analyzed microdissected single tubules from human with shotgun proteomics.
ORGANISM(S): Homo sapiens (Human) 
2018-06-28 | PXD006897 | Pride
Human Proximal tubule Kidney 
TranscriptomicsTranscription profiling of human testicular tissue histologically scored as containing carcinoma in situ (CIS) in 50%, 75%, and 100% of the seminiferous tubules vs total RNA from testicular tissue with preserved normal and complete spermatogenesis and no CIS present
Total RNA from testicular tissue histologically scored as containing carcinoma in situ (CIS) in 50%, 75%, and 100% of the seminiferous tubules and total RNA from testicular tissue with preserved normal and complete spermatogenesis and no CIS present were isolated, amplified, labeled, and co-hybridiz...
ORGANISM(S): Homo sapiens 
2004-07-15 | E-EMBL-2 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in isolated proximal tubules and whole kidneys of rats after cisplatin-administration
To clarify the effects of cisplatin (cis-diamminedichloroplatinum II, CDDP) on the gene expression profiles in renal proximal tubules, microarray analyses were carried out using total RNA samples isolated from microdissected proximal tubules and whole kidneys. The molecular events underlying acute ...
ORGANISM(S): Rattus norvegicus 
2013-12-24 | E-GEOD-37133 | biostudies-arrayexpress
ProteomicsAedes aegypti Malpighian tubules are immunologically activated following systemic Toll activation
Canine heartworm is a widespread and potentially fatal mosquito-borne disease caused by infections with the parasitic nematode, Dirofilaria immitis. We have previously shown that systemic activation of the Toll immune pathway via silencing of the negative regulator Cactus in Aedes aegypti blocks par...
ORGANISM(S): Aedes aegypti 
2024-08-27 | PXD036225 | Pride
Aedes  hemolymph  lfq  cactus  toll 
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