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ProteomicsDifferential modifications of the C-terminal tails of alpha-tubulin isoforms and their importance for kinesin-based microtubule transport in vivo
Microtubules (MTs) are built from alpha/beta-tubulin dimers and used as tracks by kinesin and dynein motors to transport a variety of cargos, such as mRNAs, proteins, and organelles, within the cell. Tubulins are subjected to several post-translational modifications (PTMs). Glutamylation is one of t...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-07-11 | PXD035270 | Pride
Alpha-tubulin glutamylation In vivo function Axonal transport Ttll5 Microtubule transport Oogenesis 
TranscriptomicsThe tumor suppressor Rassf1a prevents mouse liver tumorigenesis and regulates levels of the oncogenic kinase Tbk1 and of beta tubulin gene expression in the liver
The tumor suppressor gene RASSF1A (Ras association domain family protein 1A) coding for a microtubule stabilizing protein is epigenetically silenced in most human cancers. As a binding partner of the kinases MST1 and MST2, the mammalian orthologues of the Drosophila Hippo kinase, RASSF1A is a potent...
ORGANISM(S): Mus musculus 
2016-05-31 | E-GEOD-73911 | biostudies-arrayexpress
GenomicsThe tubulin code during cardiac hypertrophy and failure [III]
The tubulin code during cardiac hypertrophy and failure [III]
PRJNA800426 | ENA
GenomicsThe tubulin code during cardiac hypertrophy and failure [I]
The tubulin code during cardiac hypertrophy and failure [I]
PRJNA800428 | ENA
GenomicsThe tubulin code during cardiac hypertrophy and failure [II]
The tubulin code during cardiac hypertrophy and failure [II]
PRJNA800427 | ENA
GenomicsThe tubulin code during cardiac hypertrophy and failure [IV]
The tubulin code during cardiac hypertrophy and failure [IV]
PRJNA800425 | ENA
TranscriptomicsThe tubulin code during cardiac hypertrophy and failure [IV]
A proliferated and post-translationally modified microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the “tubulin code” – the permutati...
ORGANISM(S): Homo sapiens 
2022-01-28 | GSE194394 | GEO
TranscriptomicsThe tubulin code during cardiac hypertrophy and failure [III]
A proliferated and post-translationally modified microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the “tubulin code” – the permutati...
ORGANISM(S): Mus musculus 
2022-01-28 | GSE194393 | GEO
TranscriptomicsThe tubulin code during cardiac hypertrophy and failure [II]
A proliferated and post-translationally modified microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the “tubulin code” – the permutati...
ORGANISM(S): Mus musculus 
2022-01-28 | GSE194392 | GEO
TranscriptomicsThe tubulin code during cardiac hypertrophy and failure [I]
A proliferated and post-translationally modified microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the “tubulin code” – the permutati...
ORGANISM(S): Mus musculus 
2022-01-28 | GSE194391 | GEO
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