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TranscriptomicsSmall RNA deep-sequencing identifies microRNAs and other small non-coding RNAs from human herpesvirus 6 (HHV-6B)
Roseolovirus, or human herpesvirus 6 (HHV-6) is a ubiquitous human pathogen infecting over 95% of the population by the age of two years. As with other herpesviruses, reactivation of HHV-6 can present with severe complications in immunocompromised individuals. Recent studies have highlighted the imp...
ORGANISM(S): Human herpesvirus 6B 
2012-01-01 | E-GEOD-34196 | biostudies-arrayexpress
ProteomicsA cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization.
a. Human microglia play a pivotal role in neurological diseases, but few targeted therapies that directly modulate microglial state or function exist due to an incomplete understanding of microglial heterogeneity. We use single-cell RNA sequencing to profile live human microglia from autopsies or su...
ORGANISM(S): Homo sapiens (Human) 
2025-05-19 | PXD033844 | Pride
A. microglia  single-cell rna sequencing  neurodegeneration  neuroinflammation  disease-associated microglia  alzheimer’s  rnascope-immunofluorescence  microglial model systems  drug targets in neurodegeneration  camptothecin  diapasef  timstofpro 
TranscriptomicsSmall RNA deep sequencing identifies viral microRNAs during malignant catarrhal fever induced by alcelaphine herpesvirus 1
Alcelaphine herpesvirus 1 (AlHV-1) is a ?-herpesvirus (?-HV) carried asymptomatically by wildebeest. Upon cross-species transmission, AlHV-1 induces an acute and fatal lymphoproliferative disease named malignant catarrhal fever (MCF) in many ruminants, including cattle and the rabbit model. Latency ...
ORGANISM(S): Bos taurus 
2015-08-27 | E-GEOD-71056 | biostudies-arrayexpress
TranscriptomicsDegradation of cellular miR-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.
Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the cellular miR-27a and miR-27b. Here, we report tha...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-34475 | biostudies-arrayexpress
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