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GenomicsPolycomb-like 3 is a PRC2 component that supports embryonic stem cell self-renewal
Polycomb repressive complex 2 (PRC2) trimethylates lysine 27 of histone H3 (H3K27me3), which regulates gene expression and controls diverse biological transitions in development, embryonic stem cell (ESC) differentiation, and cancer. Here we show that Polycomb-like 3 (Pcl3) is a component of PRC2 t...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-28325 | biostudies-arrayexpress
ProteomicsPharmacological perturbation of the phase-separating protein SMNDC1
SMNDC1 is an essential splicing factor that, like its better-studied paralog SMN, binds to di-methylated arginines using its Tudor domain. The specific contributions of the SMNDC1 Tudor domain to protein-protein interactions, subcellular localization, and molecular function have not been studied in ...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-04 | PXD037092 | Pride
Pancreatic alpha cells Tudor domain Small molecule inhibitor Nmr structure Nuclear speckles Splicing Chemical screening 
TranscriptomicsINTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (SNP data)
Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-35329 | biostudies-arrayexpress
TranscriptomicsRNA clamping by Vasa assembles a piRNA Amplifier complex on transposon transcripts
Germline-specific Piwi-interacting RNAs (piRNAs) protect the genome against selfish genetic elements and are essential for fertility in animals. piRNAs targeting active transposons are amplified by a feed-forward loop known as the Ping-pong cycle, which links endonucleolytic slicing of target RNA...
ORGANISM(S): Bombyx mori 
2014-06-04 | E-GEOD-57420 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocytes from a patient with a heterozygous deletion of the CARMA1 gene cultured with anti-CD3, anti-CD3 and anti-CD28 or lipopolysaccharide
PBMCs were isolated from whole blood taken from one patient and one healthy control. Cells were cultured in media (RPMI) alone, with 1µg/ml anti-CD3, with 1µg/ml anti-CD3 & 1µg/ml anti-CD28 or with 0.5ng/ml LPS. Cells were harvested after 24 or 48 hours, RNA isolated using Trizol, purified using R...
ORGANISM(S): Homo sapiens 
2022-04-01 | E-MTAB-101 | biostudies-arrayexpress
TranscriptomicsINTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (CGH)
Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-35367 | biostudies-arrayexpress
TranscriptomicsINTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (expression)
Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-35082 | biostudies-arrayexpress
TranscriptomicsExpression data from U-87 human glioma cells with proficient and deficient NF-кB after treatment with temozolomide
The transcription factor, NF-кB, plays a central role in the response to DNA damage. This ubiquitous family of proteins is made up of five subunits: p50 (NF-κB1, p105), p52 (NF-κB2, p100), p65 (relA), relB, and crel that appear in their mature form as dimers. Following stimulation, NF-κB dimers tran...
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-65363 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human serum starvation cell lines for 24hrs, 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56
Study the effects of serum starvation for 24hrs on 4 cell types - TERV, TERV-ST, TERV-ST110, TERV-ASB56.
ORGANISM(S): Homo sapiens 
2004-10-01 | E-MEXP-156 | biostudies-arrayexpress
ProteomicsEvaluation of Orbitrap Ascend Tribrid Mass Spectrometer for Shotgun Proteomics
The Orbitrap Ascend Tribrid mass spectrometer was systematically evaluated in the context of shotgun proteomics, and its performance was compared to that of the previous generation of Tribrid instrument - Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-03-10 | MSV000091467 | MassIVE
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