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MetabolomicsHost autophagy mediates organ wasting and nutrient mobilization for tumor growth
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through ...
2021-09-24 | MTBLS2771 | MetaboLights
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
UnknownCancer stem cell immunology: key to understanding tumorigenesis and tumor immune escape?
Not available
S-EPMC4114188 | biostudies-literature
TranscriptomicsRNAseq of tumor samples from CT26 syngeneic mouse treated with a PI3Ka/d inhibitor (AZD8835)
PI3K inhibitors with differential selectivity to distinct PI3K isoforms have been tested extensively in clinical trials, largely to target tumor epithelial cells. PI3K signaling also regulates the immune system and inhibition of PI3Kdelta modulate the tumor immune microenvironment of pre-clinical mo...
ORGANISM(S): Mus musculus 
2019-01-08 | E-MTAB-7386 | biostudies-arrayexpress
UnknownHigh-content CRISPR screening in tumor immunology.
Not available
S-EPMC9721350 | biostudies-literature
UnknownDynamic Tumor Immunology-on-a-Chip for Peripheral Blood-Derived Tumor-Reactive T Cell Expansion.
Not available
S-EPMC11927211 | biostudies-literature
UnknownMetabolic rewiring directs melanoma immunology.
Not available
S-EPMC9393691 | biostudies-literature
UnknownTumor immunology and cancer immunotherapy: summary of the 2014 SITC primer
Not available
S-EPMC4469248 | biostudies-literature
UnknownA systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice.
Not available
S-EPMC2699142 | biostudies-literature
ProteomicsExtracellular vesicles from pancreatic cancer cells activate mast cells which in turn promote tumor cell proliferation and establish a tumor-supportive microenvironment
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
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