Tumor microenvironment

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Unknown (34080)
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Organisms

Homo sapiens (3181)
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synthetic construct (12)
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mouse gut metagenome (1)
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Francisella tularensis subsp. mediasiatica (1)
Mycobacterium canetti (1)
Mycobacterium tuberculosis variant microti (1)
Rickettsia prowazekii (1)

Organisms

Homo sapiens (2490)
Mus musculus (2317)
Canis lupus familiaris (16)
Rattus norvegicus (15)
unidentified (7)
Danio rerio (6)
Mus (4)
Drosophila melanogaster (4)
Homo sapiens/Mus musculus xenograft (3)
human gut metagenome (3)
mouse gut metagenome (3)
mouse metagenome (2)
Bacteroides fragilis (2)
Mus musculus musculus (2)
Homo (1)
Shewanella oneidensis MR-1 (1)
Mesocricetus auratus (1)
uncultured bacterium (1)
Mus (1)
Equus caballus (1)
human metagenome (1)
Macaca mulatta (1)
Mus musculus domesticus (1)
Mammalia (1)
human feces metagenome (1)
Escherichia coli (1)
Felis catus (1)
Bacteria (1)
gut metagenome (1)

Repository

ENA (5829)
geo (4761)
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pride (417)
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Tissue

Cell culture (126)
Epithelial cell (50)
Brain (31)
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Liver (15)
Permanent cell line cell (13)
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Pancrease (1)

Disease

Breast cancer (49)
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Glioblastoma (13)
Multiple myeloma (12)
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Cancer (2)
Osteosarcoma (2)
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Tumor bearing (1)
Large cell carcinoma (1)
Oropharynx squamous-cell carcinoma in DiseaseLocation oropharynx has DiseaseStaging lymph node negative (N0) (1)
Spindle cell tumor (1)
Basal cell carcinoma, Gorlin-Goltz syndrome (1)
Follicular lymphoma (1)
Lung large cell carcinoma (1)
Invasive carcinoma (1)
None (1)
Pelvic tumor (1)
Gastric cancer (1)
Solid Tumor (1)
Carcinoma, Renal Cell (1)
Neoplasm Metastasis (1)
Colorectal cancer (1)
Colonic Neoplasms (1)
Gastrointestinal Neoplasms (1)
Adenoma (1)

Technology Type

Mass Spectrometry (417)
Shotgun proteomics (217)
Bottom-up proteomics (102)
Data-dependent acquisition (54)
Data-independent acquisition (33)
Affinity purification coupled with mass spectrometry proteomics (29)
Mass spectrometry assay (25)
Mass spectrometry (23)
Top-down proteomics (18)
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MEMA (11)
Fluorescence intensity (11)
SWATH MS (11)
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NMR spectroscopy (4)
Proteogenomics (4)
Mass spectrometry imaging (3)
All-ion fragmentation (3)
DiaPASEF (3)
ILLUMINA, Illumina HiSeq 2500 (2)
Aperio (2)
Illumina HiSeq 3000, Illumina HiSeq 2000, Illumina HiSeq 4000, ILLUMINA (1)
NextSeq 500, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina (1)
Illumina HiSeq 2000 (1)
Glycoproteomics (1)
RNA mass spectrometry (1)
Immunopeptidomics (1)
MSE (1)

Instrument Platform

Illumina NovaSeq 6000 (51)
NextSeq 500 (19)
Illumina HiSeq 4000 (15)
Illumina HiSeq 2500 (14)
NextSeq 550 (7)
Illumina HiSeq 2000 (6)
Illumina HiSeq 1500 (5)
Illumina NovaSeq X (4)
NextSeq 2000 (4)
DNBSEQ-T7 (3)
10x Chromium (2)
N/A (2)
BGISEQ-500 (2)
Illumina MiSeq (2)
NextSeq 550 (Illumina). (1)
NanoString nCounter (1)
Chromium Controller with Chromium Next GEM Single Cell 5’ and V(D)J (kits v1.1) (1)
BD Rhapsody Sequence Analysis Pipeline (1)
Aurora Cytek Cs 5L (1)
D1000 ScreenTape Analysis, Qubit Fluorometer. (1)
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Novogene in-house automated library preparation system (1)
Novogene automated library prep system (1)
Qiagen RNA extraction kit (1)
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Animal Experiment Facility (1)
SPF Animal Room (1)
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Publication Date

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2023 (637)
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2020 (293)
2019 (182)
2013 (141)
2016 (140)
2018 (128)
2014 (126)
2015 (120)
2017 (107)
2011 (90)
2012 (76)
2010 (54)
2009 (42)
2008 (33)
2007 (10)
2006 (10)
2005 (6)

UNIPROT ID/AC

P05121 (1)
Q969D9 (1)
P13501 (1)
P42768 (1)
Q13480 (1)
P22692 (1)
P53779 (1)
P17936 (1)
Q8WU20 (1)
P10398 (1)
Q9BXX0 (1)
Q9NXG6 (1)
P11487 (1)
P13725 (1)
P08620 (1)
P15036 (1)
Q15746 (1)
P15514 (1)
P21781 (1)
P63261 (1)
P68032 (1)
P60709 (1)
P04004 (1)
Q9Y5S2 (1)
Q5VT25 (1)
P01583 (1)
O75116 (1)
P42830 (1)
P12644 (1)
P14921 (1)

CHEBI ID

CHEBI:15428 (11)
CHEBI:18012 (10)
CHEBI:17268 (9)
CHEBI:30769 (9)
CHEBI:16027 (9)
CHEBI:27897 (9)
CHEBI:17822 (9)
CHEBI:28044 (9)
CHEBI:18186 (9)
CHEBI:16010 (8)
CHEBI:15891 (8)
CHEBI:15354 (8)
CHEBI:15756 (8)
CHEBI:32816 (8)
CHEBI:16449 (8)
CHEBI:6650 (8)
CHEBI:22660 (8)
CHEBI:27266 (8)
CHEBI:16811 (8)
CHEBI:30915 (8)
CHEBI:25017 (8)
CHEBI:25094 (8)
CHEBI:78320 (8)
CHEBI:17015 (7)
CHEBI:30887 (7)
CHEBI:18132 (7)
CHEBI:16704 (7)
CHEBI:16335 (7)
CHEBI:15741 (7)
CHEBI:30413 (1)

Metabolite Name

Hypoxanthine (12)
Xanthine (12)
Creatine (11)
Uracil (10)
Adenosine (10)
Guanine (10)
Glycine (10)
Thymine (9)
Pyridoxine (9)
Creatinine (9)
Choline (9)
Valine (8)
Tyrosine (8)
Phenylalanine (8)
Lactate (8)
Taurine (8)
Uridine (8)
Leucine (7)
Methionine (7)
Lysine (7)
Asparagine (7)
Alanine (7)
Myo-Inositol (7)
Threonine (7)
Riboflavin (7)
Glutamine (7)
Adenine (7)
Inosine (7)
Aspartate (6)
Histidine (6)

First Public Date

2025 (1234)
2026 (1218)
2024 (948)
2023 (687)
2022 (476)
2021 (323)
2020 (287)
2019 (191)
2014 (182)
2018 (100)
2017 (94)
2016 (41)
2015 (41)
2013 (7)

Modelling Approach

Ordinary differential equation model (14)
Boolean model (3)
Other (1)
Logical model (1)

Study status

Recruiting (12)
Completed (8)
Not yet recruiting (6)
Active, not recruiting (3)
Not provided (3)
Withdrawn (1)
Terminated (1)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (8)
CRUK Beatson Institute (4)
Director of Women’s Health Research Women’s Service Line Inova Health System (4)
Moffitt Cancer Center Tampa, FL, USA (4)
Dept. of Laboratory Medicine, University of California, San Francisco, CA (3)
National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China (3)
Clinical Laboratory of BGI Health, BGI-Shenzhen, Shenzhen 518083, China (3)
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (3)
OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (3)
Department of Physiology and Biophysics, University of Illinois at Chicago (3)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (3)
Department of Biotechnology, School of Chemical & Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India (2)
Women’s Service Line Ionva Health System (2)
Elson S. Floyd College of Medicine, Washington State University Spokane (2)
Department of Medical Biotechnology and Laboratory Science College of Medicine, Chang Gung University, Taoyuan, Taiwan (2)
Koç University, Department of Molecular Biology and Genetic Cell Biology Lab head (2)
First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (2)
changzhi medical college (2)
Merck & Co., Inc. (2)
Faculty of Medicine and University Hospital of Cologne, Institute of Pathology, University of Cologne, Cologne, Germany (2)
Tufts University (2)
Spanish National Cancer Research Center (CNIO) (2)
Roswell Park Cancer Center Buffalo, NY, USA (2)
Brain Injury Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Head Trauma, Shanghai, China, 200127. (2)
Monash University (2)
UCSF (2)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (2)
Keck MS & Proteomics Resource Yale School of Medicine (2)
Tranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany (2)
Massachusetts Institute of Technology (2)

Keyword

Pembrolizumab (3)
Pancreatic ductal adenocarcinoma (2)
Immune checkpoints (2)
Flow-cytometry (2)
Albumin-Bound Paclitaxel (2)
Tumor microenvironment (2)
Gemcitabine (2)
Durvalumab (2)
Paclitaxel (2)
Gastric (gastroesophageal cancer) (1)
CD39 (1)
Adenosine Pathway (1)
Immunotherapy Immuno-oncology (1)
Budigalimab (1)
TTX-030 (1)
Urothelial cell cancer (1)
PD-1 Checkpoint Inhibitor (1)
ABBV-181 (1)
Exhaustive genetic and immunological analyses (1)
Targeted therapies (1)
Immunological tumor microenvironment (1)
Tumor microenvironment heterogeneity (1)
Nab-Paclitaxel (1)
Epacadostat (1)
IDO inhibitor (1)
Microenvironment colorectal tissue (1)
Immune infiltrate (1)
Nab-paclitaxel (1)
Anesthetics (1)
Radical resection of colorectal tumor (1)

IsPrivate

False (21)

Model Flag

Non Kinetic (1)

Submitter Keywords

Immuno-oncology (7)
Not Peer Reviewed (2)

Classification

bacteria (3)

Modification

4x(15)N labeled L-arginine (3)
2x(15)N labeled L-lysine (2)
79.966331 (1)
4x(2)H labeled dimethylated residue (1)
-18.010565 (1)
-17.026549 (1)
42.010565 (1)
15.994915 (1)
57.021464 (1)
Not available (1)

Study type

Transcription profiling by array (480)
RNA-seq of coding RNA (85)
RNA-seq of coding RNA from single cells (40)
Methylation profiling by array (16)
Other (7)
ChIP-seq (7)
Human - High-throughput sequencing (6)
Spatial transcriptomics by high-throughput sequencing (6)
Unknown experiment type (5)
Comparative genomic hybridization by array (5)
MicroRNA profiling by array (5)
RNA-seq of non coding RNA from single cells (3)
ChIP-chip by tiling array (3)
Genotyping by array (3)
Transcription profiling by RT-PCR (3)
ATAC-seq (3)
ScATAC-seq (3)
Single nucleus RNA sequencing (3)
RNA-seq of total RNA (3)
RNA-seq of non coding RNA (3)
Cell line - One-color microarray (2)
Human - One-color microarray (2)
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DNA-seq (2)
Baseline (1)
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Human - Two-color microarray (1)
Animal - One-color microarray (1)
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Release Date

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2020 (2593)
2019 (1571)
2018 (1211)
2017 (962)
2016 (910)
2015 (698)
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2014 (542)
2013 (370)
2012 (245)
2011 (232)
2010 (148)
2009 (108)
2008 (81)
2006 (31)
2007 (24)
2005 (16)
2004 (5)
2003 (2)
2002 (2)
2000 (2)
1997 (1)

Location

China (9)
France (7)
United States (5)
Italy (4)
Turkey (3)
Spain (3)
Belgium (2)
South Korea (2)
Germany (1)
Switzerland (1)

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Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells, a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables the adaptation to these co...

2022-04-29 | MTBLS4722 | MetaboLights

Obesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine prostate assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3317 | MetaboLights

Obesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine serum assays)

2024-04-10 | MTBLS3316 | MetaboLights

Adipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling_Lipidomics_amino

Upon penetrating the basement membrane, breast cancer cells directly interact with their surrounding adipose tissue, which forms a unique tumor-associated adipose microenvironment (TAME). However, the underlying mechanism involved in the regulation of lipid metabolic remodeling in the TAME remain...

2025-04-30 | MTBLS12287 | MetaboLights

Adipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling

2025-04-30 | MTBLS12286 | MetaboLights

Adipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling

2025-04-30 | MTBLS12405 | MetaboLights

Adipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling_untargeted metabolites_Lipidomics

2025-04-30 | MTBLS12289 | MetaboLights

Adipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling_Medium and long chain fatty acids

2025-04-30 | MTBLS12290 | MetaboLights

Adipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling_Medium and long chain fatty acids_four group

2025-04-30 | MTBLS12291 | MetaboLights

LiX2019 - macrophage polarization and tumor cell plasticity

This model is based on: Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment. Abstract: Tumor microenvironments contain multiple cell types interacting among one another via different signaling pathways. Furthermore, both ca...

2019-09-23 | MODEL1909230002 | BioModels

Immuno-oncology

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