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Transcriptomicsp53 and p73 ChIP-chip experiments in HCT116-3(6) cells
The p53-family of transcription factors share a highly homologous DNA binding domain and have overlapping and distinct biological functions. Using chromatin immunoprecipitation in combination with NimbleGen promoter arrays and a Model-based Algorithm for Promoter arrays (MAP), we performed a direct ...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-GEOD-12224 | biostudies-arrayexpress
GenomicsChIP-Seq of human H1299 lung carcinoma cells - genomic location data for ectopic p73
The integral role of p53 in tumor suppression has promted many laboratories to perform extensive analyses of signaling pathways downstream of the p53 family of sequence-specific DNA binding transcription factors (p53 and its homologs p63 and p73). Despite the ability of p73 to regulate many p53 fam...
ORGANISM(S): Homo sapiens 
2009-08-30 | E-GEOD-11672 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouseB-cell lymphomas with defined genetic alterations in p53 or p73
Induction of apoptosis by the tumor suppressor p53 is known to protect from Myc-driven lymphomagenesis. The p53 family member p73 is also a pro-apoptotic protein, which is activated in response to oncogenes like Myc. We therefore investigated whether p73 provides a similar protection from Myc-driven...
ORGANISM(S): Mus musculus 
2008-12-05 | E-MEXP-1620 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human p73 over-expressing H1299 cells
The integral role of p53 in tumor suppression has promted many laboratories to perform extensive analyses of signaling pathways downstream of the p53 family of sequence-specific DNA binding transcription factors (p53 and its homologs p63 and p73). Despite the ability of p73 to regulate many p53 fam...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-11626 | biostudies-arrayexpress
TranscriptomicsExpression data from rapamycin treatment and/or p73 knock-down in Rh30 cells
p73 is a p53 family transcription factor that plays critical roles during development and tumor suppression. We analyzed p73 activity using a combination of ChIP-on-Chip and gene expression profiling, both at baseline and after treatment with the mTOR inhibitor rapamycin. We generated an mTOR-p73 g...
ORGANISM(S): Homo sapiens 
2011-01-05 | E-GEOD-15703 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of DeltaNp73 alpha expressing C2C12 myoblasts examined 6 and 24 hours after shifting the cells to a differentiation medium to study the functions of the individual members of P53 family.
The p53 family comprises the tumor suppressor p53 and the structural homologs p63 and p73. How the three family members cooperate in tumor suppression remains unclear. Here, we report different but complementary functions of the individual members for regulating retinoblastoma protein (RB) function ...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5447 | biostudies-arrayexpress
UnknownFunctional association between Wwox tumor suppressor protein and p73, a p53 homolog.
Not available
S-EPMC384759 | biostudies-literature
UnknownStructural basis for ASPP2 recognition by the tumor suppressor p73.
Not available
S-EPMC3472557 | biostudies-literature
UnknownEffect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73.
Not available
S-EPMC2711048 | biostudies-literature
ProteomicsInteractome of the oncogenic deltaNp73alpha isoform in human papillomavirus 38 E6/E7-transformed keratinocytes
DeltaNp73alpha is a major oncogenic isoform of tumor suppressor p73. We report deltaNp73alpha protein binding partners in the organelle and cytoplasmic compartments of a cellular model consisting of human keratinocytes transformed by the E6 and E7 oncoproteins of the beta-HPV38 virus, which is assoc...
ORGANISM(S): Homo sapiens (Human) 
2024-12-06 | PXD056377 | Pride
Human keratinocytes Tumor suppressor p73 Interactome 
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