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Transcriptomicsepithelial-mesenchymal interaction of the breast
These 95 arrays are the basis for Figure 2 of our manuscript "An interferon-response induced by tumor-stroma interaction in a subset of human breast cancers". Abstract:Background Communication between different cell types is a cardinal feature of multi-cellular organisms and perturbations ...
ORGANISM(S): Homo sapiens 
2007-11-13 | E-GEOD-7260 | biostudies-arrayexpress
TranscriptomicsExosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways [set 1]
Stromal communication with cancer cells can influence treatment response. We show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive chemotherapy and radiation resistance. Upon heterotypic interaction, exosomes are transferred from stromal to BrCa cells. ...
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-60994 | biostudies-arrayexpress
TranscriptomicsExosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways [set 2]
Stromal communication with cancer cells can influence treatment response. We show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive chemotherapy and radiation resistance. Upon heterotypic interaction, exosomes are transferred from stromal to BrCa cells. ...
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-60995 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced in the stromal cell line EL08-1D2 by co-culture with leukemic B cells (CLL)
Tumor cell survival critically depends on heterotypic communication with benign cells in the microenvironment. Here we describe a novel survival signaling pathway activated in stromal cells by contact to B-cells from chronic lymphocytic leukemia (CLL) patients. The expression of PKC-M-NM-2II and th...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-36414 | biostudies-arrayexpress
TranscriptomicsEffect of NF-kappaB activation in bone marrow stromal cells co-cultured with CLL cells
Tumor cell survival critically depends on heterotypic communication with benign cells in the microenvironment. Here we describe a novel survival signaling pathway activated in stromal cells by contact to B-cells from chronic lymphocytic leukemia (CLL) patients. The expression of PKC-M-NM-2II and th...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-36415 | biostudies-arrayexpress
ProteomicsThe transcriptional landscape of metastatic hormone-naïve prostate cancer
Background Metastatic hormone-naïve prostate cancer (mHNPC) is an infrequent form of this tumour type that is characterized by metastasis at the time of diagnosis and accounts for 50% of prostate cancer-related deaths. Despite the extensive characterization of localized and metastatic castration res...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD063665 | Pride
Metastatic driver Single-cell transcriptomics Hormone-naïve Tumor-stromal heterotypic communication Prostate cancer Cancer cell reprogramming 
UnknownEffect of homotypic and heterotypic interaction in 3D on the E-selectin mediated adhesive properties of breast cancer cell lines.
Not available
S-EPMC3515853 | biostudies-literature
TranscriptomicsEffect of NF-kappaB activation in bone marrow stromal cells co-cultured with CLL cells
Tumor cell survival critically depends on heterotypic communication with benign cells in the microenvironment. Here we describe a novel survival signaling pathway activated in stromal cells by contact to B-cells from chronic lymphocytic leukemia (CLL) patients. The expression of PKC-βII and the subs...
ORGANISM(S): Mus musculus 
2013-03-08 | GSE36415 | GEO
TranscriptomicsExosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways [set 2]
Stromal communication with cancer cells can influence treatment response. We show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive chemotherapy and radiation resistance. Upon heterotypic interaction, exosomes are transferred from stromal to BrCa cells. ...
ORGANISM(S): Homo sapiens 
2014-10-24 | GSE60995 | GEO
TranscriptomicsExosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways [set 1]
Stromal communication with cancer cells can influence treatment response. We show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive chemotherapy and radiation resistance. Upon heterotypic interaction, exosomes are transferred from stromal to BrCa cells. ...
ORGANISM(S): Homo sapiens 
2014-10-24 | GSE60994 | GEO
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