Sort   by:  
 Page size 
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
MetabolomicsPlasma metabolomic profiling for hepatocellular carcinoma diagnosis and microvascular invasion prediction
Altered metabolites play a crucial role in the development and progression of hepatocellular carcinoma (HCC). In this study, an untargeted metabolomic analysis was conducted to identify novel biomarkers with high sensitivity and specificity for the early detection of HCC and to explore their functio...
2025-07-02 | MTBLS11996 | MetaboLights
ModelsTumour Cell Invasion and Migration
Understanding the etiology of metastasis is very important in clinical perspective, since it is estimated that metastasis accounts for 90% of cancer patient mortality. Metastasis results from a sequence of multiple steps including invasion and migration. The early stages of metastasis are tightly co...
5884 | Cell Collective
TranscriptomicsExpression data from oral squamous cell carcinoma (OSCC)-derived cell lines and normal oral keratinocytes
Oral squamous cell carcinoma (OSCC) is a lethal disease and early death usually occurs as a result of local invasion and regional lymph node metastases. We used microarrays to identify down or upregulated genes in OSCCs compared with non-malignant controls. To identify genes whose transcription is d...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-31853 | biostudies-arrayexpress
GenomicsDecoding glioblastoma invasion: single-cell profiling of environmental and cell cycle effects in tumour assembloids
Decoding glioblastoma invasion: single-cell profiling of environmental and cell cycle effects in tumour assembloids
PRJNA1271001 | ENA
ModelsMalinzi2018 - tumour-immune interaction model
The paper describes a spatio-temporal mathematical model, in the form of a moving boundary problem, to explain cancer dormancy is developed. Created by COPASI 4.24 (Build 197) Abstract: A spatio-temporal mathematical model, in the form of a moving boundary problem, to explain cancer dormancy is deve...
2024-09-02 | BIOMD0000000809 | BioModels
Immuno-oncology 
GenomicsDisruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumour invasion.
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumour invasion.
PRJNA781214 | ENA
UnknownModes of invasion during tumour dissemination.
Not available
S-EPMC5423224 | biostudies-literature
ModelsOwen1998 - Tumour treatment model
Owen1998 - tumour treatment model This model is described in the article: Modelling the macrophage invasion of tumours: effects on growth and composition. Owen MR, Sherratt JA. IMA J Math Appl Med Biol 1998 Jun; 15(2): 165-185 Abstract: Even in the early stages of the...
2024-09-02 | BIOMD0000000650 | BioModels
Sort   by:  
 Page size