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TranscriptomicsMYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Hepatocellular carcinoma is generally refractory to clinical treatment. Here, we report that inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive liver cancers. MYC inactivation resulted en masse in tumour cells differentiating into hepatocytes and biliary cells ...
ORGANISM(S): Mus musculus 
2005-07-28 | E-GEOD-3018 | biostudies-arrayexpress
ProteomicsStromal Changes in The Aged Lung Induce an Emergence From Melanoma Dormancy
Disseminated cancer cells (DCCs) that escape the primary site can seed in distal tissues, but may take several years, or even decades to grow out into overt metastases, a phenomenon termed tumor dormancy. Despite its importance in metastasis and residual disease, few studies have been able to succes...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-03 | MSV000088977 | MassIVE
TranscriptomicsCellular adhesion promotes prostate cancer cells escape from dormancy
Dissemination of prostate cancer (PCa) cells to the bone marrow is an early event in the disease process. In some patients, following initial treatment, disseminated tumor cells (DTC) proliferate to form active metastases after a prolonged period of undetectable disease known as tumor dormancy. Iden...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-64262 | biostudies-arrayexpress
ModelsMalinzi2018 - tumour-immune interaction model
The paper describes a spatio-temporal mathematical model, in the form of a moving boundary problem, to explain cancer dormancy is developed. Created by COPASI 4.24 (Build 197) Abstract: A spatio-temporal mathematical model, in the form of a moving boundary problem, to explain cancer dormancy is deve...
2024-09-02 | BIOMD0000000809 | BioModels
Immuno-oncology 
TranscriptomicsComparative genomic hybridization of oncogene inactivated liver tumors
Hepatocellular carcinoma is generally refractory to clinical treatment. Here, we report that inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive liver cancers. MYC inactivation resulted en masse in tumour cells differentiating into hepatocytes and biliary cells ...
ORGANISM(S): Mus musculus 
2005-07-21 | E-SMDB-2975 | biostudies-arrayexpress
UnknownNR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes.
Not available
S-EPMC4313575 | biostudies-literature
GenomicsMYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Hepatocellular carcinoma is generally refractory to clinical treatment. Here, we report that inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive liver cancers. MYC inactivation resulted en masse in tumour cells differentiating into hepatocytes and biliary cells ...
ORGANISM(S): Mus musculus 
2005-07-28 | GSE3018 | GEO
UnknownCancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy.
Not available
S-EPMC5882314 | biostudies-literature
UnknownDeciphering genetic and nongenetic factors underlying tumour dormancy: insights from multiomics analysis of two syngeneic MRD models of melanoma and leukemia.
Not available
S-EPMC11370043 | biostudies-literature
UnknownA generalizable relationship between mortality and time-to-death among breast cancer patients can be explained by tumour dormancy.
Not available
S-EPMC6745044 | biostudies-literature
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