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MetabolomicsRegional HNSCC metabolomics reveals widespread changes to one-carbon metabolism and S-adenosylmethionine metabolism across tumour core, tumour edge and adjacent non-tumour tissues

Cancer, including head and neck squamous cell carcinoma (HNSCC), induces changes to metabolism that drive the disease. Regional metabolomics can help to understand metabolic variation across the tumour including changes near the tumour core, where hypoxia is likely more pronounced. We apply ultra...

2026-06-03 | MTBLS1905 | MetaboLights
MetabolomicsCharacterizing ex vivo models for studying lipid metabolism in triple negative breast cancer

Lipid metabolism drives cancer progression but is difficult to model using conventional methods. In vivo models provide circulating lipids, but are costly and low throughput, while in vitro models lack sufficient lipid availability in culture media. Here, we evaluate the chick chorioallantoic mem...

2026-07-16 | MTBLS13377 | MetaboLights
GenomicsProduction of hiPSC-based tumour models
Production of hiPSC-based tumour models
PRJNA777945 | ENA
TranscriptomicsRNA-seq of human ex vivo ovarian cancer models - part III
Ascites or solid tumour samples from patients with ovarian cancer were collected and grown in culture as ex vivo models of purified tumour cells. RNA-seq was performed on these models to establish gene expression profiles, which allow identification of genes that are differentially expressed between...
ORGANISM(S): Homo sapiens 
2021-10-10 | E-MTAB-11000 | biostudies-arrayexpress
GenomicsEpigenome analysis of hiPSC-based tumour models II
Epigenome analysis of hiPSC-based tumour models II
PRJNA777943 | ENA
GenomicsEpigenome analysis of hiPSC-based tumour models I
Epigenome analysis of hiPSC-based tumour models I
PRJNA777944 | ENA
TranscriptomicsWhole transcriptome profiling of 79 patient derived xenograft (PDX) models
RNA-Seq and a species-specific mapping strategy were used to profile the human and mouse transcriptomes of tumour samples taken from 79 PDX models representing multiple cancer types (19 x breast, 37 x lung, 8 x colorectal, 7 x ovarian, 3 x endometrial, 2 x pancreatic, 2 x ampullary, 1 x leukaemia).
ORGANISM(S): Mus musculus 
2016-03-01 | E-MTAB-3980 | biostudies-arrayexpress
TranscriptomicsRNA of Small Cell Lung Cancer Circulating Tumour Cells Derived Explants
RNA-seq data characterising small cell lung cancer within circulating tumour cell (CTC) derived explants, generated within immune compromised mice. Both chemo naive and progression models were taken from patients and their drug sensitivity tested within the mouse models. Blood samples were taken fro...
ORGANISM(S): Homo sapiens 
2020-04-26 | E-MTAB-8465 | biostudies-arrayexpress
GenomicsCharacterisation of human in vitro tumour-associated macrophage models to define translational relevance
Characterisation of human in vitro tumour-associated macrophage models to define translational relevance
PRJNA1265639 | ENA
ModelsLolas2016 - tumour-induced neoneurogenesis and perineural tumour growth
The paper describes a model of tumour-induced neoneurogenesis and perineural tumour growth. Created by COPASI 4.25 (Build 207) This model is described in the article: Tumour-induced neoneurogenesis and perineural tumour growth: a mathematical approach Georgios Lolas, Arianna Bianchi and Konstant...
2024-09-02 | BIOMD0000000750 | BioModels
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