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ProteomicspH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy
Tumour-associated macrophages (TAMs), as one of the most abundant and phagocytic tumour-infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune suppression. M2-like TAMs present a heightened lysosomal acidity and protease activity, which limits the function of antigen c...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-29 | PXD044911 | Pride
Tumour-associated macrophages 
GenomicsTranscriptomic analysis of tumour-associated macrophages in wildtype and Colec11-/- mice
Transcriptomic analysis of tumour-associated macrophages in wildtype and Colec11-/- mice
PRJNA796290 | ENA
GenomicsEducation of tumour-associated macrophages by the tumour matrisome inhibits immune surveillance
Education of tumour-associated macrophages by the tumour matrisome inhibits immune surveillance
PRJNA772736 | ENA
TranscriptomicsSingle cell RNA-sequencing of epithelial cells, endothelial cells and macrophages from mouse submandibular salivary glands
The salivary glands often become damaged in individuals receiving radiotherapy for head and neck cancer, resulting in chronic dry mouth. This leads to detrimental effects on their health and quality of life, for which there is no regenerative therapy. Macrophages are the predominant immune cell in t...
ORGANISM(S): Mus musculus 
2023-10-01 | E-MTAB-13374 | biostudies-arrayexpress
TranscriptomicsExpression data from in vitro-induced non-hypoxic tumour associated macrophages (TAMs)
Active immunotherapy is a promising strategy for anti-angiogenic cancer therapy. Recently, we have reported that a vaccine using human umbilical vein endothelial cells (HUVECs) induced specific anti-endothelial immune responses in the most of immunized patients, and resulted in tumor regression in s...
ORGANISM(S): Mus musculus 
2012-03-31 | E-GEOD-18804 | biostudies-arrayexpress
GenomicsSPP1+ macrophages in HR+ breast cancer are associated with tumour-infiltrating lymphocytes.
SPP1+ macrophages in HR+ breast cancer are associated with tumour-infiltrating lymphocytes.
PRJNA1088841 | ENA
TranscriptomicsAn Ets2-specific transcriptional program in tumor-associated macrophages promotes metastasis
Macrophages have been implicated in breast cancer progression and metastasis, but relatively little is known about the genes and pathways that are involved. Using a conditional allele of Ets2 in the mouse, we have identified Ets2 as a critical gene in tumor associated macrophages (TAMs) that specif...
ORGANISM(S): Mus musculus 
2010-01-05 | E-GEOD-12863 | biostudies-arrayexpress
ProteomicsDYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant immunosuppressive and fibrotic tumor microenvironment (TME). Future therapeutic attempts therefore demand targeting of both compartments in order to be effective. We show here that Dual Specificity and Tyrosine...
ORGANISM(S): Mus Musculus 
2024-01-02 | MSV000093747 | MassIVE
TranscriptomicsTranscriptom analysis of differentially regulated genes in metastasis associated macrophages(MAM) compared with lung and spleen resident macrophages
Gene expression changes in metastasis associated macrophage (MAM) FACS sorted cells from mice bearing pulmonary metastasis of breast tumor cells were compared with lung and spleen resident macrophages sorted from healthy mice using same sorting protocol. A six chip study using total RNA recovered ...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-68862 | biostudies-arrayexpress
GenomicsM1hot tumour associated macrophages are positively associated with tissue-resident memory T cell responses and survival outcomes in human lung cancer (bulk).
M1hot tumour associated macrophages are positively associated with tissue-resident memory T cell responses and survival outcomes in human lung cancer (bulk).
PRJNA480670 | ENA
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