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ProteomicsNetwork analysis of the CSF proteome characterises convergent pathways of cellular dysfunction in ALS
Amyotrophic lateral sclerosis is a clinical syndrome with complex biological determinants, but which in most cases is characterised by TDP-43 pathology. The identification in CSF of a protein signature of TDP-43 network dysfunction would have the potential to inform the identification of new biomark...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD024219 | Pride
Wgcna Amyotrophic lateral sclerosis Cerebrospinal fluid Motor neuron disease Proteome Network analysis 
ProteomicsTDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord
Neuronal and glial cytoplasmic inclusions positive for TAR DNA-binding protein 43 (TDP-43) are the defining pathological hallmark of 97% of amyotrophic lateral sclerosis (ALS) and 50% of frontotemporal dementia (FTD). The ALS-FTD clinicopathological spectrum variably involves cortical and spinal ant...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD067060 | Pride
Proteomics Tissue Brain Tdp-43 Amyotrophic lateral sclerosis Spinal cord 
UnknownCorrection of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair.
Not available
S-EPMC7399532 | biostudies-literature
UnknownHuman iPSC co-culture model to investigate the interaction between microglia and motor neurons.
Not available
S-EPMC9308778 | biostudies-literature
UnknownC9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.
Not available
S-EPMC10517114 | biostudies-literature
UnknownC9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Not available
S-EPMC4979662 | biostudies-literature
UnknownBrainstem neurochemical profiles after hospitalisation for COVID-19: a 7T MR spectroscopy study.
Not available
S-EPMC12568683 | biostudies-literature
UnknownHigh Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.
Not available
S-EPMC5455698 | biostudies-literature
UnknownPrediction and Classification of Alzheimer's Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers.
Not available
S-EPMC6805777 | biostudies-literature
UnknownDevelopment and validation of the food allergy severity score.
Not available
S-EPMC9298738 | biostudies-literature
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