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MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
ProteomicsAccessibilome of Human Glioblastoma
Functional targeted therapy has unfortunately failed to improve the outcome of glioblastoma patients. Success stories evidenced by the use of antibody-drug conjugates in other tumor types are encouraging, but targets specific to glioblastoma and accessible through the blood stream remain scarce. In ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2014-10-17 | PXD001398 | Pride
Biomarkers  perivascular  targeted therapy 
ProteomicsHs_Glioblastoma
Accessibilome of Human Glioblastoma
ORGANISM(S): Homo Sapiens (human) 
2014-12-31 | PAe005158 | PeptideAtlas
ProteomicsEffects of FSCN1 inactivation on protein expression in human adrenocortical cancer cells
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 in e...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-18 | MSV000090738 | MassIVE
UnknownHost succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein
Not available
S-SCDT-EMBOJ-2021-108306P | biostudies-other
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