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UnknownEpigenetic Alterations Affecting Transcription Factors and Signaling Pathways in Stromal Cells of Endometriosis.
Not available
S-EPMC5268815 | biostudies-literature
TranscriptomicsMSNP data for normal blood, normal bone marrow, CD34+ cells and placenta samples
A novel method for detecting genome-wide ASM (allele-specific methylation) was developed by modification of the Affymetrix 250K StyI SNP arrays. Using this method, and the above mentioned samples, we consistently detected ASM in non-imprinted regions of the genome. Interestingly, ASM appears to be s...
ORGANISM(S): Homo sapiens 
2008-05-10 | E-GEOD-11409 | biostudies-arrayexpress
TranscriptomicsTrans-effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-74519 | biostudies-arrayexpress
TranscriptomicsGenes activated by 5-aza-dC (DAC) in pancreatic cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42366 | biostudies-arrayexpress
TranscriptomicsAltered DNA Methylation in Leukocytes with Trisomy 21
The primary abnormality in Down syndrome (DS), trisomy 21, is well known, but how this chromosomal gain produces the complex DS phenotype, including immune system defects, is not well understood. We profiled DNA methylation in total peripheral blood leukocytes (PBL) and T-lymphocytes from adults wit...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-25395 | biostudies-arrayexpress
TranscriptomicsGenes activated by 5-aza-dC (DAC) in pancreatic (KPC-Brca1) cancer-associated fibroblasts (CAFs)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer we used the DNA demethylating drug 5-aza-2’-deoxycytidine (DAC) in a KrasLSL-G12D; p53LSL-R270H/+; Pdx1-cre; Brca1flex2/flex2 (KPC-Brca1) mouse model of agg...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42364 | biostudies-arrayexpress
TranscriptomicsGenes activated by 5-aza-dC (DAC) in pancreatic cancer (KPC-Brca1) epithelial cells
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer we used the DNA demethylating drug 5-aza-2’-deoxycytidine (DAC) in a KrasLSL-G12D; p53LSL-R270H/+; Pdx1-cre; Brca1flex2/flex2 (KPC-Brca1) mouse model of agg...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42365 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human WT1-mutant versus WT1 wild-type Wilms tumors
Gain-of-function mutations in exon 3 of beta-catenin (CTNNB1) are specific for Wilms' tumors that have lost WT1, but 50% of WT1-mutant cases lack such "hot spot" mutations. To ask whether stabilization of beta-catenin might be essential after WT1 loss, and to identify downstream target genes, we com...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6120 | biostudies-arrayexpress
TranscriptomicsHDACI and DAC induce specific epigenetic profile in DLBCL
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoid neoplasm in the world representing 30-40% of all lymphomas. Standard immunochemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab) ensures cure in 60 to 65% of patients, while the rest progress or r...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-27226 | biostudies-arrayexpress
TranscriptomicsBone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
Carcinoma-associated fibroblasts (CAFs) that express ?-smooth-muscle-actin (?SMA+) contribute to cancer progression, but their precise origin and role in tumorigenesis is not established. Using mouse models of inflammation-induced gastric cancer, we show that at least 20% of CAFs originate from bone...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-23548 | biostudies-arrayexpress
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