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GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
Transcriptomicsp53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer.
Anaplastic thyroid carcinoma (ATC) has among the worst prognosis of any solid malignancy. The low incidence of the disease has in part precluded systematic clinical trials and tissue collection, and there has been little progress in developing effective therapies. BRAF and TP53 mutations co-occur ...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-55933 | biostudies-arrayexpress
TranscriptomicsNuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed only after it has metastasized to distant sites (Meuwissen and Berns 2005; Cooper and Spiro 2006). Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels (Forgacs ...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29533 | biostudies-arrayexpress
TranscriptomicsSuppression of Lung Adenocarcinoma Progression by Nkx2-1
Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-p...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26874 | biostudies-arrayexpress
MetabolomicsGNPS - GNPS Paper Novel Stenothricin Analog Supporting Information.
Mass spectrometry data, NMR, and sequencing data in support of the discovery of stenothricin-GNPS. Secondary metabolite production of Streptomyces Roseosporus was compared against Streptomyces DSM5940.
ORGANISM(S): Streptomyces (ncbitaxon:1883) 
2015-07-30 | MSV000079204 | GNPS
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