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ProteomicsSignatures of Cysteine Oxidation on Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults
Human muscle biopsies from older adults were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-17 | MSV000093136 | MassIVE
TranscriptomicsComparative genomic hybridization of samples from 30 humans and 30 chimpanzees to survey copy number variation in these species
Sixty-one array-CGH experiments were performed on the human WGTP platform, comparing: (1) 30 unrelated chimpanzees to a single chimpanzee reference individual, (2) 30 unrelated humans to a single human reference individual and (3) the chimpanzee reference individual to the human reference individual...
ORGANISM(S): Pan troglodytes 
2008-08-28 | E-TABM-479 | biostudies-arrayexpress
TranscriptomicsNuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed only after it has metastasized to distant sites (Meuwissen and Berns 2005; Cooper and Spiro 2006). Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels (Forgacs ...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29533 | biostudies-arrayexpress
ProteomicsAn Integrative SP3 Workflow for Multi-PTM Proteomics Profiling
Global proteomic, redox proteomic, and phosphoproteomic data from mouse C10 epithelial cells and skeletal muscle tissue, no treatments used for method development experiments using these biological sytems. Global proteomic, redox proteomic, phosphoproteomic, and acetylomic data from mouse Beta-TC-6 ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-07-06 | MSV000095264 | MassIVE
UnknownmiRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity
Not available
S-SCDT-10_1038-S44319-024-00253-Z | biostudies-other
no omics definedTiling path analysis to determine copy-number variation in 40 Utah/Morman and Yoruban population samples using NimbleGen technology
A copy-number variation (CNV) analysis was run on 40 CEU and YRI samples across an array set tiling across the human genome. The array contained 42 million oligos spread across 20 arrays. The final design provided 1 probe per 50bp average density across the genome.

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ORGANISM(S): Homo sapiens 
2009-04-01 | E-MTAB-40 | biostudies-arrayexpress
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
TranscriptomicsGermline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase, and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. To interrogate the functional requirement for PKM2 during development and tissue homeostasis, we generated ge...
ORGANISM(S): Mus musculus 
2016-03-25 | E-GEOD-79535 | biostudies-arrayexpress
TranscriptomicsSuppression of Lung Adenocarcinoma Progression by Nkx2-1
Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-p...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26874 | biostudies-arrayexpress
TranscriptomicsGenotyping of human copy-number variation using Agilent 2x105K
Copy-number variation (CNV) genotyping was run on 450 HapMap samples using a custom targeted array. The array contained 105 000 oligos targeted to about 10 000 CNVs.
ORGANISM(S): Homo sapiens 
2009-10-07 | E-MTAB-142 | biostudies-arrayexpress
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