Type-1 diabetes mellitus

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Transcriptomics (856)
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Proteomics (208)
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Clinical (7)
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Multiomics (1)

Organisms

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mouse gut metagenome (1)
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Organisms

Homo sapiens (59)
Mus musculus (43)
Rattus norvegicus (7)
Meriones unguiculatus (2)
Danio rerio (2)
Mus sp. (1)
Sus scrofa (1)
human gut metagenome (1)

Repository

biostudies-arrayexpress (837)
ENA (155)
pride (121)
EGA (92)
geo (79)
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MassIVE (58)
iProX (11)
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dbGaP (8)
BioModels (7)
jPOST (6)
EVA (3)
GPMDB (3)
GNPS (2)
ExpressionAtlas (1)
PAXDB (1)

Tissue

Blood plasma (16)
Cell culture (13)
Liver (9)
Pancreatic islet (8)
Blood serum (7)
Islet of Langerhans (7)
Type B pancreatic cell (7)
Blood cell (5)
Hepatocyte (5)
Kidney (5)
Pancreas (4)
Adipose tissue (3)
B cell (3)
Blood (3)
Brain (3)
Pancreatic islet beta cell (3)
Retina (3)
Artery (2)
CD4-positive helper T cell (2)
Feces (2)
Heart (2)
Helper T-lymphocyte (2)
Macrophage (2)
Pancreatic islet cell (2)
Permanent cell line cell (2)
Testis (2)
Abdominal adipose tissue (1)
HaCaT cell (1)
MIN6-N8 cell (1)
T cell (1)

Disease

Type 1 diabetes mellitus (50)
Type 2 diabetes mellitus (46)
Diabetes mellitus (9)
Normal (7)
Obesity (3)
Pre-diabetic (2)
Type I diabetes mellitus (1)
Familial combined hyperlipidemia (1)
Insulitis and diabetes (1)
Aggressive insulitis (1)
Nondiabetic (1)
Diabetes mellitus type 1 (1)
Replicate control (1)
Mild hyperglycemia (1)
Mild hyperglycemia, liver dysfunction, and renal glycosuria (1)
Controled disease patient (1)
Gestational diabetes mellitus (1)
Type 1 Diabetes Mellitus (1)
Disease controled patient (1)
Diabetes, diabetic peripheral neuropathy (1)
NGT (1)
Coronary artery disease (1)
Controled disease patient (1)
Disease controled patient (1)
Pre diabetic (1)
No disease (1)
Prostate cancer (1)
Healthy donor tissue (1)
Diabetic (1)
Type 1 diabetes mellitus (DM-1) (1)

Technology Type

Mass Spectrometry (121)
Shotgun proteomics (66)
Mass spectrometry (53)
Bottom-up proteomics (21)
Mass spectrometry assay (17)
Data-independent acquisition (17)
Data-dependent acquisition (12)
Top-down proteomics (8)
SWATH MS (7)
NMR spectroscopy (5)
Affymetrix 500K, unknown (4)
Illumina HiSeq 2000 (4)
Affinity purification coupled with mass spectrometry proteomics (4)
Gel-based experiment (4)
SRM/MRM (4)
Unknown, Affymetrix 500K (3)
DiaPASEF (2)
HiSeq X Ten, ILLUMINA (1)
ILLUMINA, Illumina Genome Analyzer IIx, Illumina HiSeq 2500 (1)
ILLUMINA, Illumina HiSeq 2500 (1)
Illumina (1)
Illumina 450K, Bisulfite-Seq (1)
Illumina HumanExome-12v1_A-GenCall, zCall, GenoSNP, - Illuminus (1)
Illumina HumanHap 550 (1)
ZCall, Illumina HumanExome-12v1_A-GenCall (1)
NMR spectroscopy assay (1)
All-ion fragmentation (1)
Immunopeptidomics (1)
Metaproteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (23)
Illumina HiSeq 2500 (14)
NextSeq 500 (8)
Illumina HiSeq 2000 (6)
Affymetrix Fluidics Station 400 (5)
Agilent G2565AA and G2565BA Microarray Scanner (4)
Illumina HiSeq 4000 (3)
Illumina iScan (2)
Illumina Genome Analyzer (2)
Illumina Genome Analyzer IIx (2)
Illumina HiSeq 1000 (2)
Illumina MiSeq (2)
NextSeq 550 (2)
Chromium Controller, 10x Genomics and Chromium X, 10x Genomics (1)
Chromium Controller, 10x Genomics and Chromium X, 10x Genomics (1)
Cell culture (1)
C1000 Touch PCR thermal cycler (Bio-Rad) (1)
10X Genomics Chromium Single Cell Kit (1)
10x genomic Chromium controller (1)
Wollenberger tongs (1)
Covaris (1)
Computer and Applied Biosystems 7500 Real Time PCR Systems thermal cycler (1)
Agilent Surescan High Resolution DNA microarray Scanner (1)
Ilumina HiScan H166 (1)
Qubit (1)
Agilent DNA Microarray Scanner Model #G2565BA (1)
Agilent Surescan High Resolution DNA Microarray Scanner (1)
HP GeneArray [Affymetrix/HP] (1)
DNA Microarray Scanner BA [Agilent Technologies] (1)
G2565BA DNA microarray scanner [Agilent] (1)

Publication Date

2014 (116)
2010 (108)
2012 (99)
2015 (98)
2013 (96)
2016 (71)
2025 (69)
2011 (66)
2009 (57)
2026 (56)
2022 (53)
2023 (45)
2008 (41)
2024 (40)
2021 (34)
2020 (31)
2007 (30)
2019 (27)
2017 (24)
2018 (21)
2006 (14)
2005 (5)
2004 (4)

UNIPROT ID/AC

P01308 (5)
P06213 (3)
P35568 (3)
O60343 (2)
P01584 (2)
P14672 (2)
P18510 (2)
P23443 (2)
P31751 (2)
P42345 (2)
P62753 (2)
Q6R327 (2)
Q8N122 (2)
O00330 (1)
O00757 (1)
O75390 (1)
P00338 (1)
P00558 (1)
P01275 (1)
P04406 (1)
P05062 (1)
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P06737 (1)
P06744 (1)
P07195 (1)
P07864 (1)
P08559 (1)
P09104 (1)
P09467 (1)
P09622 (1)

CHEBI ID

CHEBI:36080 (3)
CHEBI:17234 (2)
CHEBI:52217 (2)
CHEBI:15346 (1)
CHEBI:15351 (1)
CHEBI:15377 (1)
CHEBI:15422 (1)
CHEBI:15713 (1)
CHEBI:15846 (1)
CHEBI:15946 (1)
CHEBI:15996 (1)
CHEBI:16001 (1)
CHEBI:16027 (1)
CHEBI:16077 (1)
CHEBI:16108 (1)
CHEBI:16526 (1)
CHEBI:16761 (1)
CHEBI:16905 (1)
CHEBI:16908 (1)
CHEBI:17552 (1)
CHEBI:17659 (1)
CHEBI:17794 (1)
CHEBI:17835 (1)
CHEBI:18066 (1)
CHEBI:18357 (1)
CHEBI:24636 (1)
CHEBI:28087 (1)
CHEBI:28602 (1)
CHEBI:29052 (1)
CHEBI:30744 (1)

Metabolite Name

Creatine (15)
Hypoxanthine (13)
L-Glutamine (13)
L-Phenylalanine (13)
L-Serine (13)
L-Tyrosine (13)
Uracil (13)
Adenine (12)
L-Arginine (11)
L-Threonine (11)
Taurine (11)
Uridine (11)
L-Glutamic acid (10)
L-Isoleucine (10)
Thymine (10)
Uric acid (10)
Xanthine (10)
Cytosine (9)
Glycine (9)
L-Histidine (9)
L-Methionine (9)
Linoleic acid (9)
Palmitic acid (9)
Spermidine (9)
Adenosine (8)
Cholesterol (8)
Cholic acid (8)
Choline (8)
Creatinine (8)
Guanosine (8)

First Public Date

2024 (28)
2014 (21)
2025 (20)
2023 (16)
2026 (14)
2022 (12)
2019 (11)
2020 (7)
2021 (6)
2017 (6)
2015 (5)
2016 (4)
2018 (3)
2013 (2)

Modelling Approach

Ordinary differential equation model (7)

Study status

Recruiting (4)
Active, not recruiting (2)
Completed (1)

Lab affiliation

Biological Sciences Division, Pacific Northwest National Laboratory (4)
Pacific Northwest National Laboratory (3)
Department of Immunotechnology, Lund University (2)
Professor of biochemistry, deputy head of department Biomarker Research Group - group leader Department of Biochemistry and Molecular Biology Faculty of Medicine University of Debrecen 4032 Debrecen, Egyetem ter 1. (2)
1Nutrient Metabolism & Signalling Laboratory, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia. 2Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Victoria 3800, Australia. (1)
AdventHealth von Weller Family Chair in Type 1 Diabetes Research Associate Investigator, Translational Research Institute (1)
Alitea Biotechnology GmbH (1)
Army Military Medical University (1)
Associate Professor Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy FOE Diabetes Research Center University of Iowa (1)
Biomarker Research Group - group leader Department of Biochemistry and Molecular Biology Faculty of Medicine University of Debrecen Hungary (1)
Biomedical Innovation Department, CICESE, México (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. Netherlands Proteomics Centre, Padualaan 8, 3584 CH Utrecht, The Netherlands. (1)
CABIMER (1)
CABIMER-University of Sevilla (1)
Cancer & Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ  Integrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA  (lab head) (1)
Catholic University of Leuven, Laboratory of Clinical and Experimental Endocrinology, Leuven, Belgium (1)
Cell Biology and Physiology, Washington University in St. Louis (1)
Center for Innovative Engineering Technology in Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, China (1)
Center for Integraive Genomics (CIG), University of Lausanne, 1015 Lausanne, Switzerland (1)
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China; (1)
Center for Translational Biomedical Research, University of North Carolina at Greensboro (1)
Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P. R. China. (1)
Clinical and Experimental Endocrinology Department, KU Leuven, Leuven, Belgium (1)
College of Medicine, Department of Medical Sciences, University of Sharjah, Sharjah, UAE Center of Excellence of Precision Medicine, Sharjah Institute for Medical Research, Sharjah, UAE Research Institute of Medical and Research Sciences, Sharjah, UAE (1)
Cornell University (1)
Departemnt of Clinical Medicien, University of bergen, 5021, Bergen, Norway (1)
Department of Applied Chemistry, Institute of Natural Science, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin, 17104, South Korea. (1)
Department of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, (1)
Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland Department of Science, Faculty of Science, University of Zürich, Zürich, Switzerland (1)
Department of Biomedical Science, University of Copenhagen, Denmark (1)

Keyword

Animal protein (2)
Diet (2)
Plant protein (2)
4p-/Wolf-Hirschhorn Syndrome (1)
Autosomal recessive extra oral halitosis (1)
Batten Disease (1)
Behcet’s Disease (1)
CACNA1H mutation (1)
Chronic recurrent multifocal osteomyelitis (CRMO) (1)
Dimethylglycine dehydrogenase deficiency (1)
Hemophagocytic Lymphohistiocytosis (HLH) (1)
Hereditary Sensory and Autonomic Neuropathy (1)
Hypersomnia (1)
Intestinal Bromhidrosis Syndrome (1)
Jansen metaphyseal chondrodysplasia (1)
Legumes (1)
Marinesco-Sjogren Syndrome (1)
Mitochondrial aminoacyl-tRNA synthetases (Mt-aaRS Disorders) (1)
Mucolipidosis (1)
Mucolipidosis IV (1)
Neglected Diseases (1)
Nephropathic infantile cystinosis (1)
Ocular cystinosis (1)
Orphan Diseases (1)
Rare Disease Research (1)
Red meat (1)
Registries (1)
Shine Syndrome (1)
Spinal Bulbar Muscular Atrophy (SBMA) (1)
Uncommon Disease (1)

IsPrivate

False (7)

Model Flag

Non Kinetic (1)

Study type

Transcription profiling by array (612)
RNA-seq of coding RNA (75)
Methylation profiling by array (29)
ChIP-seq (26)
RNA-seq of coding RNA from single cells (13)
RNA-seq of non coding RNA (9)
Unknown experiment type (8)
Transcription profiling by RT-PCR (8)
Methylation profiling by high throughput sequencing (7)
Other (6)
MicroRNA profiling by array (6)
Comparative genomic hybridization by array (5)
ChIP-chip by tiling array (4)
ChIP-chip by array (4)
Genotyping by array (3)
MicroRNA profiling by high throughput sequencing (3)
Bisulfite-seq (2)
DNA-seq (2)
RNA-seq of total RNA (2)
FAIRE-seq (1)
Transcription profiling by SAGE (1)
Animal - One-color microarray (1)
Human - Methylation microarray (1)
Human - Single-cell sequencing (1)
Human - High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
MBD-seq (1)
ATAC-seq (1)
Single nucleus RNA sequencing (1)
Proteomic profiling by array (1)

Release Date

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2008 (67)
2007 (36)
2006 (20)
2005 (12)
2004 (8)
2000 (2)
1998 (2)
2003 (1)
2001 (1)

Location

United States (3)
Australia (1)
Belgium (1)
Finland (1)
Germany (1)

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Circulating Metabolites in Progression to Islet Autoimmunity and Type 1 Diabetes

AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a cir...

2022-01-19 | MTBLS802 | MetaboLights

Omega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus

Background

Omega-3 polyunsaturated fatty acids (PUFAs) are known to protect against type 1 diabetes mellitus (T1DM), but how they act through the gut-islet axis is not fully understood. This study explored how Omega-3 PUFA-influenced gut microbiota and their metabolites help protect pancrea...

2026-06-13 | MTBLS13006 | MetaboLights

Omega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus

Background

2026-06-13 | MTBLS13174 | MetaboLights

Metabolic alterations in immune cells associate with progression to type 1 diabetes

AIMS: Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreat...

2020-08-10 | MTBLS1015 | MetaboLights

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes: Type 1 Diabetes Prediction and Prevention Study (DIPP)

Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 pl...

2018-07-16 | MTBLS620 | MetaboLights

Omega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus_fecal_Omega-3 PUFAs

Background

2026-06-13 | MTBLS13979 | MetaboLights

Serum metabolomic profile in children with type 1 diabetes mellitus: an exploratory targeted metabolomics study of candidate discriminatory features

Background: Type 1 diabetes mellitus (T1DM) is an increasingly common chronic disease caused by autoimmune damage to pancreatic beta cells. Metabolomic profiling may provide insights into metabolic disturbances associated with T1DM and identify candidate biomarkers. Methods: The study included 29 ch...

2026-09-22 | MTBLS15768 | MetaboLights

EFO: In preparation - Early Metabolic Predictors of Type 2 Diabetes Mellitus in Normoglycemic Adults: Insights from Six-Year Prospective Cohort Study

INTRODUCTION: Type 2 Diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, often preceded by latent metabolic disruptions. Early detection of metabolic alterations can facilitate timely intervention to delay or prevent T2DM onset. Metaboli...

2025-08-04 | MTBLS10965 | MetaboLights

Disorders of gut microbiota and fecal-serum metabolic patterns are associated with pulmonary tuberculosis and pulmonary tuberculosis co-morbid type 2 diabetes mellitus

BACKGROUND: Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are prevalent chronic diseases with substantial implications for human health. DM patients are more susceptible to PTB, which exacerbates diabetes-related complications. However, the complex molecular mechanisms ...

2023-12-15 | MTBLS8729 | MetaboLights

Proteomics of high density lipoprotein subfractions in type 1 diabetes mellitus and controls

Toyoshima MTK. Proteomics and functionality of high-density lipoprotein subfractions and subclinical cardiovascular disease in type 1 diabetes mellitus. Faculdade de Medicina, Universidade de Sao Paulo 2021.

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2021-08-13 | MSV000087986 | MassIVE

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AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a cir...

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