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GenomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-02-22 | E-GEOD-70729 | biostudies-arrayexpress
TranscriptomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [human cell line gene expression]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-74959 | biostudies-arrayexpress
TranscriptomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [Kras background mouse gene expression]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Mus musculus 
2016-02-22 | E-GEOD-74960 | biostudies-arrayexpress
TranscriptomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [RNA-seq]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Mus musculus 
2016-02-22 | E-GEOD-70728 | biostudies-arrayexpress
GenomicsRole of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [ChIP-seq]
Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical re...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-70624 | biostudies-arrayexpress
TranscriptomicsTargeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis
IL13R?2 overexpression promotes metastasis of basal-like breast cancers IL13R?2 depletion in highly metastatic breast cancer cells suppresses lung metastases formation by upregulating TP63 and decreasing their migratory potential MCF10CA1a (MIV) cells expressing the luciferase gene (MIV-Luc), were s...
ORGANISM(S): Homo sapiens 
2015-07-28 | E-GEOD-57677 | biostudies-arrayexpress
TranscriptomicsHippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas
The Hippo signaling pathway has become recognized as a context-dependent regulator of cell proliferation, differentiation, and apoptosis in species ranging from Drosophila to human. In this study, we sought to understand whether Hippo signaling plays a role in pancreatic development and organ homeos...
ORGANISM(S): Mus musculus 
2013-02-14 | E-GEOD-44298 | biostudies-arrayexpress
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