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UnknownModulation of extrasynaptic NMDA receptors by synaptic and tonic zinc.
Many excitatory synapses contain high levels of mobile zinc within glutamatergic vesicles. Although synaptic zinc and glutamate are coreleased, it is controversial whether zinc diffuses away from the release site or whether it remains bound to presynaptic membranes or proteins after its release. To ...
S-EPMC4443361 | biostudies-literature
UnknownTonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission.
In many synapses of the CNS, mobile zinc is packaged into glutamatergic vesicles and co-released with glutamate during neurotransmission. Following synaptic release, the mobilized zinc modulates ligand- and voltage-gated channels and receptors, functioning as an inhibitory neuromodulator. However, t...
S-EPMC4575225 | biostudies-literature
UnknownSynaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1.
The NMDA receptor (NMDAR) is inhibited by synaptically released zinc. This inhibition is thought to be the result of zinc diffusion across the synaptic cleft and subsequent binding to the extracellular domain of the NMDAR. However, this model fails to incorporate the observed association of the high...
S-EPMC7458442 | biostudies-literature
UnknownCell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage.
Peripheral sensory organ damage leads to compensatory cortical plasticity that is associated with a remarkable recovery of cortical responses to sound. The precise mechanisms that explain how this plasticity is implemented and distributed over a diverse collection of excitatory and inhibitory cortic...
S-EPMC10345144 | biostudies-literature
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