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ProteomicsMolecular insights into THUMPD2-mediated m2G methylation of the U6 snRNA
THUMPD2 installs N2-methylguanosine (m2G) at position 72 of the U6 snRNA, and this modification, which lies at the catalytic core of the spliceosome, is required for efficient splicing of weak splice sites. However, when during the U6 lifecycle this modification is installed and what features of the...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD053510 | Pride
Dia Uhplc-esi-msms U6 snrna maturation Rna methylation Thumpd2 Trmt112 
UnknownMechanism of U6 snRNA oligouridylation by human TUT1.
Not available
S-EPMC10415362 | biostudies-literature
GenomicsTUT1-catalyzed U6 snRNA 3′-end maturation is required for mRNA splicing to maintain stem cell pools during embryogenesis [RNA-Seq]
TUT1-catalyzed U6 snRNA 3′-end maturation is required for mRNA splicing to maintain stem cell pools during embryogenesis [RNA-Seq]
PRJNA1307445 | ENA
TranscriptomicsTUT1-catalyzed U6 snRNA 3′-end maturation is required for mRNA splicing to maintain stem cell pools during embryogenesis [RNA-Seq]
The post-transcriptional maturation of U6 snRNA 3′-end is important for spliceosomal assembly and RNA splicing, and is catalyzed by sequential enzymatic activities of TUT1 and USB1, that is, an oligo(U) tail is first added by TUT1 to the freshly transcribed U6 snRNA, and then trimmed by USB1 to gene...
ORGANISM(S): Mus musculus 
2026-06-03 | GSE305663 | GEO
TranscriptomicsTUT1-catalyzed U6 snRNA 3′-end maturation is required for mRNA splicing to maintain stem cell pools during embryogenesis [Nanopore long-read RNA-seq]
The post-transcriptional maturation of U6 snRNA 3′-end is important for spliceosomal assembly and RNA splicing, and is catalyzed by sequential enzymatic activities of TUT1 and USB1, that is, an oligo(U) tail is first added by TUT1 to the freshly transcribed U6 snRNA, and then trimmed by USB1 to gene...
ORGANISM(S): Mus musculus 
2026-06-03 | GSE305664 | GEO
GenomicsTUT1-catalyzed U6 snRNA 3′-end maturation is required for mRNA splicing to maintain stem cell pools during embryogenesis [Nanopore long-read RNA-seq]
TUT1-catalyzed U6 snRNA 3′-end maturation is required for mRNA splicing to maintain stem cell pools during embryogenesis [Nanopore long-read RNA-seq]
PRJNA1307441 | ENA
ProteomicsN2-methylguanosine modifications on human tRNAs and snRNA U6 are important for colon cancer cell proliferation, protein translation and pre-mRNA splicing
Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent an important layer of gene expression regulation through their ability to fine-tune mRNA maturation and transla-tion. Growing evidences support important roles of tRNA/snRNAs modifications and hence the enzymes that install...
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD038997 | Pride
Bioid experiment 
ProteomicsN2-methylguanosine modifications on human tRNAs and snRNA U6 are important for colon cancer cell proliferation, protein translation and pre-mRNA splicing
Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent an important layer of gene expression regulation through their ability to fine-tune mRNA maturation and transla-tion. Growing evidences support important roles of tRNA/snRNAs modifications and hence the enzymes that install...
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD038967 | Pride
Ap-ms experiment 
UnknownTUT1-catalyzed U6 snRNA 3′-end maturation is essential for RNA splicing and stem cell survival
Not available
S-SCDT-10_1038-S44319-026-00759-8 | biostudies-other
UnknownInitial spliceosomal U4/U6 di-snRNA formation occurs in the cytoplasm of Saccharomyces cerevisiae and requires a guard protein mediated quality control.
Not available
S-EPMC12781873 | biostudies-literature
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