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ProteomicsThe length of a ubiquitin chain is a general determinant for selective recognition by ubiquitin-binding proteins.
The attachment of differently linked ubiquitin (Ub) chains of varying length to proteins is a prevalent posttranslational modification in eukaryotic cells. The fate of a modified protein is determined by Ub-binding proteins (UBPs) that interact with Ub chains in a linkage-selective manner. Therefore...
ORGANISM(S): Homo sapiens (Human) 
2020-04-20 | PXD015877 | Pride
Chain-length Ubiquitin Ub-binding proteins Posttranslational modification 
TranscriptomicsDesigned, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
Ubiquitin (Ub) is a protein post-translational modification that controls proteostasis through mechanisms spanning transcription, translation, and protein degradation. Ub conjugation occurs through a cascade of three enzyme classes (E1, E2, and E3s) involving >1000 proteins that regulate the ubiquit...
ORGANISM(S): Homo sapiens 
2025-09-01 | GSE298221 | GEO
UnknownUbiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.
Not available
S-EPMC166409 | biostudies-literature
GenomicsDesigned, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
Designed, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
PRJNA1268535 | ENA
UnknownThe GAT domains of clathrin-associated GGA proteins have two ubiquitin binding motifs.
Not available
S-EPMC2911622 | biostudies-literature
UnknownDOA1/UFD3 plays a role in sorting ubiquitinated membrane proteins into multivesicular bodies.
Not available
S-EPMC2490793 | biostudies-literature
GenomicsFANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis
Fanconi Anemia (FA) is a rare genetic disorder characterized by an increased susceptibility to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate in a common DNA repair pathway. A critical step is the monoubiquitination of the FANCD2 protein, and cells from most...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-46902 | biostudies-arrayexpress
UnknownThe Length of a Ubiquitin Chain: A General Factor for Selective Recognition by Ubiquitin-Binding Proteins.
Not available
S-EPMC7384046 | biostudies-literature
UnknownNatural history of the E1-like superfamily: implication for adenylation, sulfur transfer, and ubiquitin conjugation.
Not available
S-EPMC2732565 | biostudies-literature
UnknownVCP/p97-associated proteins are binders and debranching enzymes of K48-K63-branched ubiquitin chains.
Not available
S-EPMC11638074 | biostudies-literature
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