Ubiquinone - OmicsDI

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Transcriptomics (3531)
Unknown (1086)
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Models (10)
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Organisms

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Organisms

Homo sapiens (17)
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Sphingobacterium sp. UT-1RO-CII-1 (1)
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Repository

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Tissue

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Disease

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DNA damage (1)
Metabolic syndrome (1)
Uninfected (1)
Pre-tumoral lesion in a mouse model of human adamantinomatous craniopharyngioma (ACP) (1)
Schizophrenia (1)
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Irritable bowel syndrome (1)
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Technology Type

Mass Spectrometry (48)
Mass spectrometry (20)
Shotgun proteomics (17)
ESI (16)
Mass spectrometry assay (10)
Bottom-up proteomics (9)
SWATH MS (4)
NMR spectroscopy (2)
Affinity purification coupled with mass spectrometry proteomics (2)
Data-dependent acquisition (2)
Illumina HiSeq 2000 (1)
Data-independent acquisition (1)
Gel-based experiment (1)
HDMSE (1)

Instrument Platform

Illumina NovaSeq 6000 (14)
NextSeq 500 (9)
Illumina HiSeq 2000 (8)
Illumina HiSeq 2500 (6)
Illumina MiSeq (4)
Illumina HiSeq 4000 (4)
Instrument (3)
GenePix 4000A [Axon Instruments] (2)
Illumina Genome Analyzer IIx (2)
Illumina Genome Analyzer II (2)
DNBelab C Series High-throughput Single-cell RNA Library Preparation Set V3.0 (MGI Tech) (1)
DNBelab C-TaiM droplet generator (MGI Tech) (1)
Avatarget 12-well dual-chamber organ-on-chip system; AvatarFlow Organ Chip Flow Initiation Controller System (Avatarget Co., Ltd., Suzhou, China) (1)
Nanodrop (1)
Lab Chip GX touch HT (Perkin Elmer) (1)
Agilent 2100 Bioanalyzer, Applied Biosystems 7900HT Sequence Detection System, Illumina TruSeq Small RNA Sample Preparation Kit (1)
RNeasy mini Kit, Ribo-Zero Human/Mouse/Rat kit (1)
Infors-HT Labfors chemostat (1)
MoFlo XPD (Beckman Coulter, Fullerton, CA, USA) flow cytometer (1)
Solexa 2G Genome Analyzer (1)
Dell PowerEdge R820 (1)
Agilent 2100 Bioanalyzer (1)
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Scanning hardware (1)
N/A (1)
NextSeq 2000 (1)
DNBSEQ-G400 (1)
MinION (1)
Illumina HiSeq 1500 (1)
NextSeq 550 (1)

Publication Date

2015 (618)
2010 (578)
2013 (503)
2011 (392)
2014 (391)
2012 (389)
2008 (191)
2016 (159)
2009 (146)
2007 (86)
2022 (48)
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2006 (27)
2021 (24)
2005 (21)
2026 (19)
2020 (18)
2018 (16)
2024 (15)
2019 (14)
2023 (13)
2004 (9)
2003 (6)
2002 (2)

CHEBI ID

CHEBI:16704 (11)
CHEBI:17568 (10)
CHEBI:16856 (9)
CHEBI:17596 (9)
CHEBI:30769 (9)
CHEBI:16708 (8)
CHEBI:15891 (8)
CHEBI:16750 (7)
CHEBI:17084 (7)
CHEBI:15428 (7)
CHEBI:18012 (7)
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CHEBI:30915 (6)
CHEBI:32816 (6)
CHEBI:6650 (6)
CHEBI:27266 (6)
CHEBI:16449 (6)
CHEBI:17268 (6)

Metabolite Name

Uridine (7)
Creatine (7)
Leucine (6)
Choline (6)
Adenosine (6)
Uracil (6)
Inosine (6)
Xanthine (5)
Inosine (5)
Hippurate (5)
Beta-alanine (5)
Alanine (5)
Glycine (5)
Spermidine (5)
Glutamate (5)
Creatinine (5)
Tyrosine (5)
Nicotinamide (5)
Betaine (5)
Adenine (5)
Hypoxanthine (5)
Creatinine (5)
Guanosine (5)
Hecogenin (4)
3-phosphoglycerate (4)
Citrate (4)
Valine (4)
Uridine (4)
Urate (4)
Taurine (4)

First Public Date

2022 (7)
2023 (6)
2021 (5)
2014 (5)
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2020 (4)
2019 (4)
2025 (3)
2018 (3)
2024 (2)
2017 (1)

Modelling Approach

Constraint-based model (8)

Study status

Recruiting (1)

Lab affiliation

Max Planck Institute for Terrestrial Microbiology Karl-von-Frisch Str. 10 35043 Marburg Germany (2)
Translational Biomarker Group, University of Geneva, Geneva, Switzerland (2)
1- Departamento de Biología Molecular, Centro de Biología Molecular "Severo Ochoa" (CBMSO), c/Nicolás Cabrera 1, Universidad Autónoma de Madrid, Madrid, Spain. 2- Instituto Universitario de Biología Molecular, IUBM, Universidad Autónoma de Madrid, Madrid, Spain. 3- Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain. 4- Instituto de Investigación Hospital 12 de Octubre, i+12, Universidad Autónoma de Madrid, Madrid, Spain. (1)
Cellular biology, Moreno lab, UGA, USA (1)
Center for Tropical and Emerging Global Diseases; Department of Cellular Biology, University of Georgia, Athens, Georgia, USA (1)
Department of Biochemistry and Molecular Biology, The Bio21 Institute, The University of Melbourne, 3000, Melbourne, Australia (1)
Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada. (1)
Department of Cellular & Molecular Physiology Milton S. Hershey Medical Center Penn State College of Medicine Hershey, PA, USA (1)
Department of Clinical and Toxicological Analysis, Federal University of Alfenas, Brazil (1)
Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, and Santa Lucia IRCCS Foundation, Rome, Italy (1)
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester, Minnesota 55905 United States (1)
Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan (1)
Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden (1)
Department of Molecular Biology and Biotechnology, University of Sheffield, UK (1)
Department of Parasitology, Institute of Biomedical Sciences of the University of São Paulo, Av. Lineu Prestes 1374, CEP 05508-000, São Paulo, SP, Brazil. Telephone: +55 11 3091-7330 Fax: 5511 3091-7417. E-mail address: amkatzin@icb.usp.br (A. M. Katzin) (1)
Département de Biologie, Université de Moncton, Moncton (NB, Canada) (1)
EDyP (1)
Institute of Plant Genetics, Leibniz Universitaet Hannover, Germany (1)
Karolinska Institute Division of Molecular Metabolism Department of Medical Biochemistry and Biophysics (1)
Laboratório de Biotecnologia, Centro de Biociências e Biotecnologia (CBB), Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Av. Alberto Lamego, Campos dos Goytacazes, RJ, Brazil. Unidade de Biologia Integrativa, Setor de Genômica e Proteômica, UENF, Campos dos Goytacazes, RJ, Brazil. (1)
Masaryk University, Faculty of Science, Department of Biochemistry (1)
Max Planck Institute for terrestrial Microbiology Karl-von-Frisch Str. 10 35043 Marburg Germany (1)
Max-Planck-Institute for Biology of Ageing Joseph-Stelzmann-Str. 9b 50931 Cologne, Germany (1)
Novo Nordisk Center For Basic Metabolic Research, Department of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark (1)
Pacific Northwest National Laboratory (1)
Rudolf Virchow Zentrum – University of Würzburg (1)
School of Biosciences, University of Sheffield (1)
The First Affiliated Hospital, Jinan University, Guangzhou, China. (1)
Universität Greifswald Institut für Pharmazie, AG Pharmazeutische Biotechnologie Greifswald, Germany (1)
VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium (1)

Keyword

Neglected Diseases (1)
Orphan Diseases (1)
Rare Disease Research (1)
Registries (1)
Batten Disease (1)
Mucolipidosis IV (1)
Undiagnosed (1)
Uncommon Disease (1)
Hypersomnia (1)
Marinesco-Sjogren Syndrome (1)
4p-/Wolf-Hirschhorn Syndrome (1)
Wiedermann-Steiner Syndrome (1)
Hemophagocytic Lymphohistiocytosis (HLH) (1)
Behcet’s Disease (1)
Jansen metaphyseal chondrodysplasia (1)
Chronic recurrent multifocal osteomyelitis (CRMO) (1)
Hereditary Sensory and Autonomic Neuropathy (1)
Nephropathic infantile cystinosis (1)
Ocular cystinosis (1)
Spinal Bulbar Muscular Atrophy (SBMA) (1)
Mucolipidosis (1)
Mitochondrial aminoacyl-tRNA synthetases (Mt-aaRS Disorders) (1)
Shine Syndrome (1)
Intestinal Bromhidrosis Syndrome (1)
Autosomal recessive extra oral halitosis (1)
CACNA1H mutation (1)
Dimethylglycine dehydrogenase deficiency (1)

IsPrivate

False (8)

Submitter Keywords

Not Peer Reviewed (7)
FROG (1)

Classification

bacteria (2)

Study type

Transcription profiling by array (2602)
RNA-seq of coding RNA (435)
Unknown experiment type (127)
RNA-seq of non coding RNA (87)
Other (42)
Comparative genomic hybridization by array (41)
ChIP-chip by tiling array (37)
Methylation profiling by array (37)
Transcription profiling by SAGE (34)
ChIP-seq (33)
Transcription profiling by tiling array (18)
Transcription profiling by RT-PCR (16)
Proteomic profiling by array (16)
Genotyping by array (6)
Methylation profiling by high throughput sequencing (5)
ChIP-chip by array (3)
MicroRNA profiling by high throughput sequencing (3)
RNA-seq of coding RNA from single cells (3)
High-throughput sequencing (2)
RNAi profiling by array (2)
DNA-seq (2)
RNA-seq of total RNA (2)
ChIP-chip by SNP array (1)
Transcription profiling by MPSS (1)
Differential (1)
Human - One-color microarray (1)
Animal - High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Proteomic profiling by mass spectrometer (1)
Bisulfite-seq (1)

Release Date

2015 (660)
2010 (603)
2013 (529)
2014 (430)
2011 (426)
2012 (417)
2008 (220)
2016 (208)
2009 (161)
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2005 (26)
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2004 (14)
2003 (8)
2001 (7)
1998 (3)
2002 (2)
2000 (2)
1996 (1)
1989 (1)

Location

Australia (1)
United States (1)

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Small molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria

We report identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus, whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching those for clinically useful antibiotics. DHB is produced by Ph...

2024-09-06 | MTBLS10720 | MetaboLights

Characterization of ND5 subunit of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I)

This project contains MALDI-TOF/TOF spectra derived from the ND5 subunit of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I).

ORGANISM(S): Bos Taurus

PXD031179 | JPOST Repository

Identification of LPS-inducible genes down-regulated by ubiquinone in human THP-1 cells

Coenzyme Q10 (CoQ10) is an obligatory element in the respiratory chain and functions as a potent antioxidant of lipid membranes. More recently, anti-inflammatory effects as well as an impact of CoQ10 on gene expression have been observed. To reveal putative effects of Q10 on LPS-induced gene express...

ORGANISM(S): Homo sapiens

2010-12-22 | E-GEOD-19625 | biostudies-arrayexpress

Elevated mitochondrial DNA copy number found in ubiquinone-deficient clk-1 mutants is not rescued by ubiquinone precursor 2-4-dihydroxybenzoate.

Not available

S-EPMC8113126 | biostudies-literature

Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool.

Not available

S-EPMC1637562 | biostudies-literature

Identification of the binding sites for ubiquinone and inhibitors in the Na⁺-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae by photoaffinity labeling.

Not available

S-EPMC5427254 | biostudies-literature

Evidence for a key role of cytochrome bo3 oxidase in respiratory energy metabolism of Gluconobacter oxydans

The obligatory aerobic acetic acid bacterium Gluconobacter oxydans oxidizes a variety of substrates in the periplasm by membrane-bound dehydrogenases, which transfer the reducing equivalents to ubiquinone. Two quinol oxidases, cytochrome bo3 and cytochrome bd, then catalyze transfer of the electrons...

ORGANISM(S): Gluconobacter oxydans 621H

2013-07-26 | E-GEOD-47782 | biostudies-arrayexpress

CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures.

Not available

S-EPMC2427298 | biostudies-literature

Biosynthesis of ubiquinone compounds with conjugated prenyl side chains.

Not available

S-EPMC2583475 | biostudies-literature

Computational Identification and Analysis of Ubiquinone-Binding Proteins.

Not available

S-EPMC7072731 | biostudies-literature