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ProteomicsUbiquitinated proteome of E15.5 murine cortical neurons
TRIM9 and TRIM67 are neuronally-enriched E3 ubiquitin ligases essential for neuronal morphogenesis and responses to the axon guidance cue netrin-1. Deletion of either gene in the mouse results in subtle neuroanatomical anomalies yet overt deficits in spatial learning and memory. The identify of few ...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021818 | Pride
Embryonic cortical neurons Ubiquitinate proteome Orbitrap fusion lumos 
UnknownLigandability of E3 Ligases for Targeted Protein Degradation Applications.
Not available
S-EPMC8928483 | biostudies-literature
UnknownHaploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.
Not available
S-EPMC3836740 | biostudies-literature
ProteomicsProxiCapture reveals context-dependent CRBN interactome landscape of molecular glue degraders
Molecular glue degraders represent a rapidly expanding class of small molecules that reprogram E3 ubiquitin ligases to ubiquitinate and degrade disease-relevant proteins. Despite their therapeutic potential, the rational design of molecular glues remains challenging, underscoring the need for unbias...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD070637 | Pride
ProteomicsProxiCapture reveals context-dependent CRBN interactome landscape of molecular glue degraders
Molecular glue degraders represent a rapidly expanding class of small molecules that reprogram E3 ubiquitin ligases to ubiquitinate and degrade disease-relevant proteins. Despite their therapeutic potential, the rational design of molecular glues remains challenging, underscoring the need for unbias...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD070621 | Pride
ProteomicsProxiCapture reveals context-dependent CRBN interactome landscape of molecular glue degraders
Molecular glue degraders represent a rapidly expanding class of small molecules that reprogram E3 ubiquitin ligases to ubiquitinate and degrade disease-relevant proteins. Despite their therapeutic potential, the rational design of molecular glues remains challenging, underscoring the need for unbias...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-02-03 | PXD070567 | Pride
ProteomicsProxiCapture reveals context-dependent CRBN interactome landscape of molecular glue degraders
Molecular glue degraders represent a rapidly expanding class of small molecules that reprogram E3 ubiquitin ligases to ubiquitinate and degrade disease-relevant proteins. Despite their therapeutic potential, the rational design of molecular glues remains challenging, underscoring the need for unbias...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-02-03 | PXD070656 | Pride
ProteomicsProxiCapture reveals context-dependent CRBN interactome landscape of molecular glue degraders
Molecular glue degraders represent a rapidly expanding class of small molecules that reprogram E3 ubiquitin ligases to ubiquitinate and degrade disease-relevant proteins. Despite their therapeutic potential, the rational design of molecular glues remains challenging, underscoring the need for unbias...
ORGANISM(S): Homo sapiens (Human) 
2026-02-03 | PXD070945 | Pride
ProteomicsProxiCapture Reveals Context-Dependent CRBN Interactome Landscape of Molecular Glue Degraders
Molecular glue degraders represent a rapidly expanding class of small molecules that reprogram E3 ubiquitin ligases to ubiquitinate and degrade disease-relevant proteins. Despite their therapeutic potential, the rational design of molecular glues remains challenging, underscoring the need for unbias...
ORGANISM(S): Homo sapiens (Human) 
2026-02-05 | PXD073192 | Pride
UnknownUbiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control.
Not available
S-EPMC10209342 | biostudies-literature
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