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GenomicsSelective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell proliferation
Selective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell proliferation
PRJNA1095926 | ENA
TranscriptomicsSelective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell proliferation
Histone deacetylase 6 (HDAC6) is overexpressed in multiple myeloma (MM) patients and may be involved in the acquisition of resistance to conventional treatments. Here, we propose a two-residue mutation impairing the HDAC6 ZnF-UBP domain. HDAC6 knockout and ZnF-UBP mutant RPMI 8226 MM cell lines were...
ORGANISM(S): Homo sapiens 
2024-04-08 | GSE263138 | GEO
UnknownTwo ZnF-UBP domains in isopeptidase T (USP5).
Not available
S-EPMC8391072 | biostudies-literature
UnknownStructural and functional studies of USP20 ZnF-UBP domain by NMR.
Not available
S-EPMC6699088 | biostudies-literature
UnknownA mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.
Not available
S-EPMC15854 | biostudies-literature
UnknownHDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins.
Not available
S-EPMC3005221 | biostudies-literature
UnknownSolution structure of the N-terminal domain of DC-UbP/UBTD2 and its interaction with ubiquitin.
Not available
S-EPMC2868252 | biostudies-literature
UnknownSelective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell function.
Not available
S-EPMC12000391 | biostudies-literature
UnknownA ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes.
Not available
S-EPMC4160250 | biostudies-literature
UnknownGenome-wide identification and characterization of UBP gene family in wheat (Triticum aestivum L.).
Not available
S-EPMC8212830 | biostudies-literature
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