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Activity-based protein profiling is a powerful chemoproteomic technique to detect active enzymes and identify targets and off-targets of drugs. Here, we report on the use of a carmofur-based activity-based probe to identify biologically relevant enzymes in the bacterial pathogen Staphylococcus aureu...
ORGANISM(S): Bacteria Staphylococcus aureus 
2024-01-29 | PXD043275 | Pride
Glycosidases fulfill crucial functions in all life forms contributing to diverse biological processes such as metabolism, cell signaling, or pathogen-host interactions. In search for new putative targets for antimicrobial drugs, we here aimed to identify and characterize retaining glycosidase activi...
ORGANISM(S): Staphylococcus aureus 
2025-05-07 | PXD052286 | Pride
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