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MetabolomicsUrban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes
Sub-Saharan Africa currently experiences an unprecedented wave of urbanization, which has important consequences for health and disease patterns. This study aimed to investigate and integrate the immune and metabolic consequences of rural or urban lifestyles and the role of nutritional changes assoc...
2021-06-22 | MTBLS2267 | MetaboLights
TranscriptomicsMannose receptor-induced T cell tolerance via interaction with CD45 and up-regulation of CTLA-4
The MR is an endocytic receptor, which plays an important role in serum homeostasis and antigen presentation. In this study, we firstly describe an important role of the MR as a direct regulator of CD8+ T cell activity. We could demonstrate that the presence of the MR on DCs impaired the cytotoxicit...
ORGANISM(S): Mus musculus 
2016-08-23 | E-GEOD-45805 | biostudies-arrayexpress
UnknownOncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways.
Not available
S-EPMC8917911 | biostudies-literature
TranscriptomicsEpigenomic landscapes of human inflammation associated macrophages [RNA-seq]
We previously demonstrated by genomic and bioinformatical approaches that human macrophage (MΦ) activation is best described by a spectrum model (Xue et al, Immunity, 2014). MΦ integrate exogenous input signals on transcriptional level in a unique fashion to generate specific functional programs, ...
ORGANISM(S): Homo sapiens 
2016-02-28 | E-GEOD-66593 | biostudies-arrayexpress
GenomicsEpigenomic landscapes of human inflammation associated macrophages [ChIP-seq]
We previously demonstrated by genomic and bioinformatical approaches that human macrophage (MΦ) activation is best described by a spectrum model (Xue et al, Immunity, 2014). MΦ integrate exogenous input signals on transcriptional level in a unique fashion to generate specific functional programs, ...
ORGANISM(S): Homo sapiens 
2016-02-28 | E-GEOD-66594 | biostudies-arrayexpress
UnknownAlveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.
Not available
S-EPMC9377018 | biostudies-literature
TranscriptomicsEssential role of formyl peptide receptor 1 in anthracycline-based anticancer chemotherapy
Tumor growth reduction induced by anthracycline-based chemotherapy is largely determined by an anticancer immune response that is ignited by the presentation of dead-cell antigens by intratumoral dendritic cells. In an unbiased screen designed to identify cancer therapy-relevant single nucleotide po...
ORGANISM(S): Mus musculus 
2016-04-04 | E-GEOD-63410 | biostudies-arrayexpress
UnknownStatus of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey.
Not available
S-EPMC12005017 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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