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MetabolomicsMetabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals
This study employs spectroscopy-based metabolic profiling of fecal extracts from healthy subjects and patients with active or inactive ulcerative colitis (UC) and Crohn's disease (CD) to substantiate the potential use of spectroscopy as a non-invasive diagnostic tool and to characterize the fecal me...
2017-02-07 | MTBLS237 | MetaboLights
ProteomicsHuman colon biopsies (healthy and Ulcerative Colitis) LC-MS/MS
The etiology of the inflammatory bowel diseases, including ulcerative colitis, remains incomplete, but recent findings points to the involvement of complex host-microbial interactions. We hypothesized that an analysis of the proteins on the host-microbial interacting surface, the intestinal mucosa, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080833 | MassIVE
MetabolomicsPaeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and its Metabolites

BACKGROUND: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the gastrointestinal tract. Recent studies demonstrate that the phenolic tannin paeonol (Pae) attenuates UC in mouse models by downregulating inflammatory factors; however, molecular mechanisms lin...

2024-09-27 | MTBLS5204 | MetaboLights
MetabolomicsDarutigenol alleviates ulcerative colitis via promoting Akkermansia muciniphila-mediated proline synthesis
Gut microbiota dysbiosis is associated with the occurrence and development of inflammatory bowel disease (IBD). Darutigenol (DL) is a natural compound with limited oral bioavailability, but has shown promise in the treatment of ulcerative colitis (UC). However, the precise mechanisms underlying its ...
2025-09-26 | MTBLS10395 | MetaboLights
TranscriptomicsTranscription profiling of human ulcerative colitis colonic mucosa to define an ulcerative colitis preinflammatory state
The samples are a part of a study aiming at diagnosing ulcerative colitis from genome-wide gene expression analysis of the colonic mucosa. Colonic mucosal samples were collected as endoscopic pinch biopsies from ulcerative colitis patients and from control subjects. Samples with and without macrosco...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-9452 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ulcerative colitis samples reveals a predictive response signature to infliximab treatment in ulcerative colitis
Infliximab, an anti-TNFa monoclonal antibody, is an effective treatment for ulcerative colitis (UC) inducing over 60% of patients to respond to treatment. Consequently, about 40% of patients do not respond. This study analyzed mucosal gene expression from patients enrolled in ACT1 to provide a predi...
ORGANISM(S): Homo sapiens 
2009-09-05 | E-GEOD-12251 | biostudies-arrayexpress
MetabolomicsElucidating the molecular mechanisms of Daifu decoction in ulcerative colitis treatment through a multi-omics framework and experimental verification

Background: Ulcerative colitis (UC) is a significant and challenging condition in the digestive system, necessitating the development of effective therapeutic interventions. The Daifu decoction (DFD) is derived from the Lizhong decoction, a classic traditional Chinese Medicine (TCM) formula used ...

2026-03-18 | MTBLS13973 | MetaboLights
TranscriptomicsMucosal gene signatures to predict response to infliximab in patients with ulcerative colitis
Infliximab, an anti-TNF-alpha monoclonal antibody, is an effective treatment for ulcerative colitis (UC) with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti-TNF-alpha is unknown. This study used colonic mucosal gene expression to pr...
ORGANISM(S): Homo sapiens 
2010-01-06 | E-GEOD-14580 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing of mucosal pinch biopsies from patients with ulcerative colitis and primary sclerosing cholangitis concomitant with colitis
Mucosal pinch biopsies from ascending, transverse, descending colon and rectum were obtained from ulcerative colitis (UC) and primary sclerosing cholangitis concomitant with colitis (PSC-UC) patients during routine endoscopies and subjected to 5' single-cell RNA sequencing
ORGANISM(S): Homo sapiens 
2026-06-17 | E-MTAB-14955 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ileum and colonic tissues from patients with Crohns disease or ulcerative colitis
Samples for microarray analysis were derived from terminal ileum and colonic tissues from probands with Crohn's disease and Ulcerative Colitis and control patients, respectively. IBD tissue biopsies from non-inflamed regions 10 cm distant from pathological areas were selected. To minimize inter-indi...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1152 | biostudies-arrayexpress
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