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TranscriptomicsAged Mice are Unable to Mount an Effective Myeloid Response to Sepsis
Old C57BL/6 mice cannot mount an effective innate immune response We used mouse microarrays to detail the molecular profile of the events that occur following infection
ORGANISM(S): Mus musculus 
2014-02-04 | E-GEOD-51925 | biostudies-arrayexpress
TranscriptomicsPost-natal age is a critical determinant of the neonatal host response to sepsis
Neonates manifest a unique host response to sepsis even among other children. Preterm neonates may experience sepsis soon after birth or during often protracted birth hospitalizations as they attain physiologic maturity. We examined the transcriptome using genome-wide expression profiling on prospec...
ORGANISM(S): Homo sapiens 
2015-07-06 | E-GEOD-69686 | biostudies-arrayexpress
TranscriptomicsAdvanced Age is Associated with Worsened Outcomes and a Unique Genomic Response in Severely Injured Patients with Hemorrhagic Shock
We performed epidemiological, cytokine, and transcriptomic analyses on a prospective, multi-center cohort of 1,928 severely injured patients. We wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with hemor...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-64711 | biostudies-arrayexpress
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