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GenomicsRNA-seq Analysis of Wild-Type and G898D UPC2A Transcriptomes [G898D UPC2A transcriptome]
RNA-seq Analysis of Wild-Type and G898D UPC2A Transcriptomes [G898D UPC2A transcriptome]
PRJNA756364 | ENA
GenomicsChIP-seq analysis of transcription factor Upc2A binding across the Candida glabrata genome [Upc2A ChIP-seq]
ChIP-seq analysis of transcription factor Upc2A binding across the Candida glabrata genome [Upc2A ChIP-seq]
PRJNA756362 | ENA
TranscriptomicsRNA-seq Analysis of Wild-Type and G898D UPC2A Transcriptomes [G898D UPC2A transcriptome]
Purpose: Determine the number of genes that respond to the presence of a gain-of-function mutant form of the UPC2A transcription factor in Candida glabrata. Methods: Prepare total RNA from wild-type and gain-of-function G898D UPC2A cells. Use standard RNA-seq to evaluate and compare the transcriptom...
ORGANISM(S): Nakaseomyces glabratus 
2021-09-23 | GSE182490 | GEO
GenomicsChIP-seq analysis of transcription factor Upc2A binding across the Candida glabrata genome [Upc2A ChIP-seq]
To determine the genomic binding sites for the Candida glabrata transcription factor Upc2A, we utilized three different strains. One was the wild-type KKY2001 which contains a wild-type copy of UPC2A but lacks any HA tag. The other two are both derived from KKY2001 but contain a 3X HA tag immediatel...
ORGANISM(S): Nakaseomyces glabratus CBS 138 
2021-09-23 | GSE182488 | GEO
GenomicsRNA-sequencing analysis of fluconazole-treated wild-type and upc2A null cells [Fluconazole]
RNA-sequencing analysis of fluconazole-treated wild-type and upc2A null cells [Fluconazole]
PRJNA756363 | ENA
UnknownUPC2A is required for high-level azole antifungal resistance in Candida glabrata.
Not available
S-EPMC4136023 | biostudies-literature
UnknownThe Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways.
Not available
S-EPMC8509923 | biostudies-literature
TranscriptomicsRNA-sequencing analysis of fluconazole-treated wild-type and upc2A null cells [Fluconazole]
Purpose: Compare the fluconazole-induced transcriptome of isogenic wild-type and upc2A null cells. Methods: Prepare total RNA from wild-type and upc2A null cells grown under unstressed conditions or challenged with 50 microgram/ml fluconazole for 6 hours. Use standard RNA-seq to evaluate and compare...
ORGANISM(S): Nakaseomyces glabratus 
2021-09-23 | GSE182489 | GEO
GenomicsLoss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2A∆ mutation in Candida glabrata, implicating additional positive regulators of ergosterol biosynthesis
Loss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2A∆ mutation in Candida glabrata, implicating additional positive regulators of ergosterol biosynthesis
PRJNA789874 | ENA
TranscriptomicsLoss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2A∆ mutation in Candida glabrata, implicating additional positive regulators of ergosterol biosynthesis
Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limited to the role of hypoxia and sterol-stress induced transc...
ORGANISM(S): Nakaseomyces glabratus 
2021-12-20 | GSE191145 | GEO
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