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ProteomicsTemporal landscape of mitochondrial proteostasis governed by the UPRmt
When mitochondrial proteostasis breaks down, quality control pathways including the UPRmt and PINK1/Parkin mitophagy are activated in response. However, beyond the upregulation of chaperones and proteases, we have a limited understanding of how the UPRmt remodels and restores damaged mito-proteomes....
ORGANISM(S): Homo sapiens (Human) 
2023-09-27 | PXD038403 | Pride
Mitochondria  metabolism  oxphos  proteostasis  uprmt  mitophagy  pink1  parkin 
GenomicsmRNA-seq of worms and the mitochondrial unfolded protein response (UPRmt)
mRNA-seq of worms and the mitochondrial unfolded protein response (UPRmt)
PRJNA591855 | ENA
UnknownThe UPRmt preserves mitochondrial import to extend lifespan.
Not available
S-EPMC9134095 | biostudies-literature
GenomicsRegulation of thin shell traits by SHP based on UPRmt pathway
Regulation of thin shell traits by SHP based on UPRmt pathway
PRJNA938505 | ENA
GenomicsA cytosolic surveillance mechanism activates the mitochondrial UPR
RNAseq UPRmt
PRJEB61069 | ENA
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75247 | biostudies-arrayexpress
TranscriptomicsMitochondrial unfolded protein response controls matrix pre-RNA processing and translation
The mitochondrial matrix is unique in that it must integrate folding and assembly of proteins derived from nuclear and mitochondrial genomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, includin...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-75410 | biostudies-arrayexpress
TranscriptomicsmRNA-seq of worms and the mitochondrial unfolded protein response (UPRmt)
To cope with a challenging and unpredictable environment, living systems have evolved several organelle-specific stress responses, e.g. the cytosolic heat shock response (HSR), the endoplasmic reticulum unfolded protein response (UPRER) and the mitochondrial unfolded protein response (UPRmt). UPRmt ...
ORGANISM(S): Caenorhabditis elegans 
2020-07-19 | GSE141041 | GEO
GenomicsSingle cell analysis of a iPSC-derived glial-neurons triculture model of mitochondrial unfolded protein response (UPRmt) activation.
Single cell analysis of a iPSC-derived glial-neurons triculture model of mitochondrial unfolded protein response (UPRmt) activation.
PRJNA1145881 | ENA
GenomicsBulk RNA sequencing analysis of a iPSC-derived neurons, microglia and astrocytes models of mitochondrial unfolded protein response (UPRmt) activation.
Bulk RNA sequencing analysis of a iPSC-derived neurons, microglia and astrocytes models of mitochondrial unfolded protein response (UPRmt) activation.
PRJNA1145868 | ENA
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