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ProteomicsA high-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC
Epitope tagging and magnetic bead enrichment were combined with SILAC quantitative proteomics to determine a high-confidence glycosome proteome for the procyclic life cycle stage of the parasite Trypanosoma brucei.
ORGANISM(S): Trypanosoma brucei 
2014-05-13 | PXD000663 | Pride
Trypanosoma brucei Orbitrap velos Ap-ms 
ProteomicsOrganising the cell cycle in the absence transcriptional control: Dynamic phosphorylation co-ordinates the Trypanosoma brucei cell cycle post-transcriptionally
The cell division cycle of the unicellular eukaryote Trypanosome brucei is tightly regulated despite the paucity of transcriptional control that results from the arrangement of genes in polycistronic units and lack of dynamically regulated transcription factors. To identify the contribution of dynam...
ORGANISM(S): Trypanosoma brucei 
2019-10-22 | PXD013488 | Pride
Trypanosoma brucei Phosphoproteomics Cell cycle Silac 
ProteomicsGenomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome
SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using a chemo-proteomic approach. SILAC-based proteomic studies using an oxaborole analogue immobilised onto ...
ORGANISM(S): Trypanosoma brucei 
2015-11-25 | PXD002848 | Pride
Trypanosoma brucei 
OtherComparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages.
RANCHE KEY: 6rtELh46IFS7gExEGuFR7E2t3UZABvuzvkh0U5sz71SSZM+XogXG2a8Omdg5+KWQCmjpP30xZWhujBngVbaqsT9ZTpYAAAAAAAAGCw== Original data file: BSF-F3-7.mgf. Data published as part of PLoS One. 2012;7(5):e36619 . From the Abstract: {{i}} ... We have optimized a procedure for growing Trypanosoma brucei pro...
ORGANISM(S): Trypanosoma_brucei_ncbi 
GPM11210003129 | GPMDB
ProteomicsMode of action studies for a novel anti-leishmania compound
We describe the development of a novel anti-leishmanial drug-like chemical series based on a pyrazolopyrimidine scaffold. The leading compound is efficacious in a mouse model of visceral leishmaniasis, and has suitable physicochemical, pharmacokinetic and toxicological properties for further develo...
ORGANISM(S): Leishmania donovani 
2018-11-30 | PXD009711 | Pride
Leishmania Chemical proteomics 
ProteomicsT.brucei - Whole organism, sequence+MS2 intensity (Urbaniaketal,jproteomeres2013)
abundance based on sequence+MS2 intensity, Interaction consistency score: 17.7, Coverage: 56
ORGANISM(S): 5691 
2013-00-00 | 4092869827 | PAXDB
ProteomicsT.brucei - Whole organism, sequence+MS2 intensity (Urbaniaketal,jproteomeres2013)
abundance based on sequence+MS2 intensity, Interaction consistency score: 17.4, Coverage: 56
ORGANISM(S): 5691 
2013-00-00 | 4181687758 | PAXDB
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