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TranscriptomicsGene regulation by phosphomimetic Myc (MycD), cytosine arabinoside (AraC) and retinoic acid (RA)
We aimed to investigate whether the previously observed synergistic effects of AraC and RA in stimulating leukemia differentiation could be at least partially dependent on Pak2-mediated phosphorylation of Myc. Genome-wide analysis of NB4 cells treated with RA, AraC with RA, or MycD with RA revealed ...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-29213 | biostudies-arrayexpress
TranscriptomicsGene regulation by phosphomimetic Myc and retinoic acid
We aimed to investigate the E-box and Max-independent functions of the oncogene Myc in gene regulation and differentiation of leukemic cells. Expression in HL60 leukemic cells of a mutant form of Myc with impaired Max and E-box interaction by replacing the phosphorylation sites of Pak2 kinase to asp...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24731 | biostudies-arrayexpress
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